默克尔细胞癌的自发消退：病例报告

Spontaneous Regression of Merkel Cell Carcinoma: Case Report.

作者信息

Bystricky Branislav, Kohutek Filip, Miklatkova Zuzana, Sedlacek Tomas, Gal Viliam, Lohajova Behulova Regina

机构信息

Oncology Department, Faculty Hospital Trencin, Trencin, Slovakia and Faculty of Healthcare, Alexander Dubcek University of Trencin, Trencin, Slovakia.

Oncology Department, Faculty Hospital Trencin, Trencin, Slovakia.

出版信息

Int Med Case Rep J. 2021 Oct 2;14:711-717. doi: 10.2147/IMCRJ.S329545. eCollection 2021.

DOI:10.2147/IMCRJ.S329545

PMID:34629908

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8495228/

Abstract

Merkel cell carcinoma (MCC) is a rare skin neuroendocrine tumor presumably arising from Merkel cells in the basal layer of epidermis. It is an aggressive tumor predominantly found on the head and neck area of elderly people, with a mortality rate around 41% for all stages. Complete spontaneous regression of MCC is seldom observed, mostly in elderly women. We describe complete spontaneous regression of large, histologically confirmed MCC in an elderly woman after biopsy, which occurred incidentally, while waiting for radical surgery with skin flap. Next-generation sequencing with SOPHiA Solid Tumor Plus Solution did not reveal any relevant gene mutations or rearrangements. An update of literature for these very rare cases is provided.

摘要

默克尔细胞癌（MCC）是一种罕见的皮肤神经内分泌肿瘤，可能起源于表皮基底层的默克尔细胞。它是一种侵袭性肿瘤，主要发生在老年人的头颈部，所有阶段的死亡率约为41%。MCC完全自发消退很少见，多见于老年女性。我们描述了一名老年女性在活检后组织学确诊的大型MCC完全自发消退的情况，这是在等待皮瓣根治性手术时偶然发生的。使用SOPHiA Solid Tumor Plus Solution进行的二代测序未发现任何相关基因突变或重排。本文提供了这些非常罕见病例的文献综述。