用于药物制剂和尿液中匹立哌唑电位流动注射分析的化学修饰碳糊电极。

Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine.

作者信息

Ibrahim Hosny

机构信息

Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.

出版信息

J Pharm Biomed Anal. 2005 Jul 15;38(4):624-32. doi: 10.1016/j.jpba.2005.02.006.

DOI:10.1016/j.jpba.2005.02.006

PMID:15967290

Abstract

A new carbon paste electrode selective for piribedil (PD) was prepared and fully characterized in terms of composition, usable pH range, response time and thermal stability. The electrode active recognition is by liquid ion-exchange mechanism via the use of piribedil phosphomolybdate as ion-exchanger dissolved in tricresyl phosphate as a more suitable solvent mediator for the paste. The modified electrode showed a Nernstian slope of 58.4+/-0.6 mV over the concentration range of 7.5 x 10(-7) to 1 x 10(-3)M with an average recovery of 98.3-101.0% and R.S.D. of 0.45-1.31%. The electrode exhibits good selectivity for PD with respect to a large number of inorganic cations, organic cations, sugars and amino acids. The developed electrode was successfully used for the potentiometric determination of PD in its aqueous solutions, pharmaceutical preparation, and urine in batch and flow injection analysis (FIA).

摘要

制备了一种对匹立哌唑（PD）具有选择性的新型碳糊电极，并对其组成、可用pH范围、响应时间和热稳定性进行了全面表征。电极的活性识别是通过液膜离子交换机制实现的，使用磷酸钼酸匹立哌唑作为离子交换剂，溶解在磷酸三甲苯酯中作为更适合糊剂的溶剂介质。修饰电极在7.5×10⁻⁷至1×10⁻³M的浓度范围内显示出58.4±0.6 mV的能斯特斜率，平均回收率为98.3 - 101.0%，相对标准偏差为0.45 - 1.31%。该电极对PD相对于大量无机阳离子、有机阳离子、糖和氨基酸具有良好的选择性。所开发的电极成功用于电位法测定水溶液、药物制剂和尿液中的PD，可进行批量分析和流动注射分析（FIA）。