流动注射电位法测定盐酸氯丁醇

Flow injection potentiometric determination of clobutinol hydrochloride.

作者信息

Issa Y M, Zayed S I M

机构信息

Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt.

出版信息

Talanta. 2006 Apr 15;69(2):481-7. doi: 10.1016/j.talanta.2005.10.018. Epub 2005 Nov 21.

DOI:10.1016/j.talanta.2005.10.018

PMID:18970592

Abstract

New clobutinol (Clob) ion-selective polyvinyl chloride (PVC) membrane electrodes, based on the ion-associates of Clob with phosphotungstic acid or phosphomolybdic acid were prepared using dibutyl phthalate as plasticizing solvent. The electrodes were characterized in terms of membrane composition, temperature and pH. The sensors showed a near-Nernstian response over the concentration ranges (6.31 x 10(-6))-(1.00 x 10(-2)) and (5.01 x 10(-5))-(1.00 x 10(-2))M in the case of clobutinol-phosphotungstate ((Clob)(3)-PT) applying batch and flow injection (FI) analysis, respectively, and (1.58 x 10(-5))-(1.00 x 10(-2)) and (5.01 x 10(-5))-(1.00 x 10(-2))M in case of clobutinol-phosphomolybdate ((Clob)(3)-PM) for batch and FI analysis systems, respectively. The electrodes were successfully applied for the potentiometric determination of ClobCl in pharmaceutical preparation and urine in steady state and flow injection conditions. The electrodes exhibit good selectivity for Clob with respect to a large number of inorganic cations, sugars and amino acids.

摘要

以邻苯二甲酸二丁酯作为增塑溶剂，基于氯丁诺与磷钨酸或磷钼酸的离子缔合物制备了新型氯丁诺（Clob）离子选择性聚氯乙烯（PVC）膜电极。对电极进行了膜组成、温度和pH方面的表征。在批量分析和流动注射（FI）分析中，对于氯丁诺 - 磷钨酸盐（(Clob)₃ - PT），传感器在浓度范围(6.31×10⁻⁶) -(1.00×10⁻²)M和(5.01×10⁻⁵) -(1.00×10⁻²)M内分别呈现近能斯特响应；对于氯丁诺 - 磷钼酸盐（(Clob)₃ - PM），在批量分析和FI分析系统中，浓度范围分别为(1.58×10⁻⁵) -(1.00×10⁻²)M和(5.01×10⁻⁵) -(1.00×10⁻²)M时呈现近能斯特响应。这些电极已成功应用于在稳态和流动注射条件下对药物制剂和尿液中氯丁诺盐酸盐（ClobCl）的电位测定。相对于大量无机阳离子、糖类和氨基酸，该电极对氯丁诺表现出良好的选择性。