Baiardini I, Pasquali M, Braido F, Fumagalli F, Guerra L, Compalati E, Braga M, Lombardi C, Fassio O, Canonica G W
Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy.
Allergy. 2005 Aug;60(8):1073-8. doi: 10.1111/j.1398-9995.2005.00833.x.
Health-related quality of Life in patients with chronic urticaria is evaluated by mean of generic instruments or questionnaire designed for skin diseases. No disease-specific tool is now available for the assessment of chronic urticaria impact from patients' viewpoint.
The aim of our study is to develop and validate a new questionnaire specifically designed for the assessment of quality of life in chronic urticaria (Chronic Urticaria Quality of Life Questionnaire -- CU-Q(2)oL).
In the development phase of CU-Q(2)oL an initial list of items of 37 items was compiled and given to 80 patients with chronic urticaria; the 23 most significant items were selected and converted into questions evaluating the answers on a Likert scale of five steps. The validation procedure involved 125 patients (86 F and 39 M) (age 42.17 +/- 9.24 years).
Following a statistical analysis, CU-Q(2)oL showed a six-dimensional structure and good levels of internal consistency for the extracted factors: Pruritus (0.79), Swelling (0.65), Impact on life activities (0.83), Sleep problems (0.77), Looks (0.83) and Limits (0.74). In stable conditions CU-Q(2)oL showed a good reliability, ranged between 0.64 and 0.92. Responsiveness to clinical changes was accomplished.
These results provide evidence that CU-Q(2)oL has specificity enough for being a valid tool for detecting the relative burden of CU on subjective wellbeing, and for obtaining a global evaluation both of CU impact and of treatments, taking into account the patient's point of view. The CU-Q(2)oL was easily and quickly filled up and well accepted by the patients.
慢性荨麻疹患者的健康相关生活质量通过通用工具或为皮肤病设计的问卷进行评估。目前尚无从患者角度评估慢性荨麻疹影响的疾病特异性工具。
我们研究的目的是开发并验证一种专门设计用于评估慢性荨麻疹生活质量的新问卷（慢性荨麻疹生活质量问卷——CU-Q(2)oL）。
在CU-Q(2)oL的开发阶段，编制了一份包含37个条目的初始清单，并将其分发给80名慢性荨麻疹患者；选择了23个最重要的条目，并将其转换为用五分量表评估答案的问题。验证程序涉及125名患者（86名女性和39名男性）（年龄42.17±9.24岁）。
经过统计分析，CU-Q(2)oL显示出六维结构，提取因素的内部一致性水平良好：瘙痒（0.79）、肿胀（0.65）、对生活活动的影响（0.83）、睡眠问题（0.77）、外观（0.83）和限制（0.74）。在稳定条件下，CU-Q(2)oL显示出良好的可靠性，范围在0.64至0.92之间。实现了对临床变化的反应性。
这些结果证明，CU-Q(2)oL具有足够的特异性，可作为检测慢性荨麻疹对主观幸福感相对负担的有效工具，并从患者角度对慢性荨麻疹的影响和治疗进行全面评估。CU-Q(2)oL易于快速填写，患者接受度良好。
