Dos Santos J G, Blanco M M, Do Monte F H M, Russi M, Lanziotti V M N B, Leal L K A M, Cunha G M
Department of Psychobiology, Neurophysiology Laboratory, Federal University of São Paulo, Rua Botucatu, 862, 5 andar, 04023-900, São Paulo, Brazil.
Fitoterapia. 2005 Sep;76(6):508-13. doi: 10.1016/j.fitote.2005.04.017.
The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids.
木贼的水醇提取物（HAE）在200和400mg/kg剂量下对旷场试验显示出显著活性，增加了转棒试验中的跌落次数，减少了在棒上停留的时间，并在巴比妥酸盐诱导的睡眠时间中增加了睡眠时间（分别增加46%和74%）。在戊四氮惊厥试验中，它延长了首次惊厥潜伏期，减轻了惊厥的严重程度，降低了出现惊厥的动物百分比（分别为50%和25%），并保护动物免于死亡。相反，在高架十字迷宫试验中，50、100和150mg/kg剂量对所评估的参数没有影响。因此，HAE具有抗惊厥和镇静作用。植物化学分析检测到含有单宁、皂苷、甾醇和黄酮类化合物。
