Yoshida Takashi, Ishiko Hiroaki, Yasuda Mitsuru, Takahashi Yoshito, Nomura Yuri, Kubota Yasuaki, Tamaki Masayoshi, Maeda Shin-ichi, Deguchi Takashi
Research and Development Department 1, Mitsubishi Kagaku Bio-Clinical Laboratories, Inc., Tokyo, Japan.
Sex Transm Dis. 2005 Jul;32(7):454-7. doi: 10.1097/01.olq.0000158932.78183.95.
Our previous study suggested a significant association between Ureaplasma urealyticum and nongonococcal urethritis (NGU). However, association of the serovars of U. urealyticum with NGU remains unclear. A polymerase chain reaction (PCR)-based assay can distinguish 4 serovars of Ureaplasma parvum from each other and categorize 10 serovars of U. urealyticum into 3 subtypes: subtype 1 (serovars 2, 5, 8, and 9), subtype 2 (serovars 4, 10, 12, and 13), and subtype 3 (serovars 7 and 11).
The goal of this study was to determine which subtypes of U. urealyticum are associated with NGU as determined by PCR-based assay.
The prevalence of U. urealyticum subtypes in 106 ureaplasma-positive men with urethritis was compared with that in 30 ureaplasma-positive men without urethritis.
: In men with nonchlamydial NGU and men with Mycoplasma genitalium-negative nonchlamydial NGU, only U. urealyticum subtype 1 (serovars 2, 5, 8, and 9) was detected significantly more often than in men without urethritis.
This study suggests that subtype 1 of U. urealyticum (serovars 2, 5, 8, and 9) is associated with NGU independently of Chlamydia trachomatis or M. genitalium.
我们之前的研究表明解脲脲原体与非淋菌性尿道炎（NGU）之间存在显著关联。然而，解脲脲原体血清型与NGU的关联仍不清楚。基于聚合酶链反应（PCR）的检测方法可以区分微小脲原体的4种血清型，并将解脲脲原体的10种血清型分为3个亚型：1型（血清型2、5、8和9），2型（血清型4、10、12和13），以及3型（血清型7和11）。
本研究的目的是通过基于PCR的检测方法确定解脲脲原体的哪些亚型与NGU相关。
比较了106例尿道炎解脲脲原体阳性男性和解脲脲原体阳性但无尿道炎的30例男性中解脲脲原体亚型的患病率。
在非衣原体性NGU男性和生殖支原体阴性的非衣原体性NGU男性中，仅解脲脲原体1型（血清型2、5、8和9）的检出率显著高于无尿道炎男性。
本研究表明，解脲脲原体1型（血清型2、5、8和9）与NGU相关，独立于沙眼衣原体或生殖支原体。
