Barry W, Hudgins L, Donta S T, Pesanti E L
University of Connecticut Health Center, Farmington.
JAMA. 1992 Jun 24;267(24):3315-6.
Staphylococcus aureus and group A Streptococcus pyogenes produce toxic shock syndrome characterized by hypotension and multisystem organ failure. While conventional therapy has consisted of antibiotics and intensive supportive care, some experimental evidence suggests that immunoglobulins directed against the toxins may be effective additional therapy. We report a case of "toxic strep syndrome" in which intravenous immunoglobulin was administered when signs and symptoms were worsening while the patient was receiving conventional therapy. Within hours of administration of the intravenous immunoglobulin, the patient experienced dramatic clinical improvement. This response suggests a possible therapeutic benefit of intravenous immunoglobulin in toxic shock syndrome.
金黄色葡萄球菌和A组化脓性链球菌可引发中毒性休克综合征，其特征为低血压和多系统器官衰竭。传统疗法包括使用抗生素和强化支持治疗，然而一些实验证据表明，针对毒素的免疫球蛋白可能是有效的辅助治疗方法。我们报告了一例“中毒性链球菌综合征”病例，该患者在接受传统治疗时症状恶化，随后给予了静脉注射免疫球蛋白。在静脉注射免疫球蛋白数小时内，患者的临床症状显著改善。这一反应表明静脉注射免疫球蛋白在中毒性休克综合征中可能具有治疗益处。
