Domingo José L
Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus, Spain.
Environ Int. 2006 Jan;32(1):121-7. doi: 10.1016/j.envint.2005.05.021. Epub 2005 Jun 24.
This paper reviews the state of the science regarding polychlorinated diphenyl ethers (PCDEs), a group of halogenated aromatic compounds, which are structurally related to polychlorinated biphenyls (PCBs) and polychlorinated dibenzofurans (PCDFs). Special attention is paid to the environmental levels, toxicity, and human exposure. PCDEs have been detected in a number of environmental samples, and their widespread occurrence in the environment is mainly the result of their presence as impurities in chlorophenol preparations. In humans, PCDE congeners have been detected in adipose tissue. As for other persistent organic pollutants (POPs), dietary intake is very probably the main route of exposure to PCDEs for the general population. However, data concerning PCDE levels in foodstuffs are very limited. It is concluded that investigations on experimental toxicity, dietary intake, and potential human health effects of PCDEs are clearly necessary.
本文综述了多氯二苯醚（PCDEs）这一卤代芳香族化合物群体的科学现状，它们在结构上与多氯联苯（PCBs）和多氯二苯并呋喃（PCDFs）相关。文中特别关注了环境水平、毒性和人体暴露情况。在许多环境样本中都检测到了PCDEs，它们在环境中的广泛存在主要是因为其作为氯酚制剂中的杂质而存在。在人体中，已在脂肪组织中检测到PCDE同系物。与其他持久性有机污染物（POPs）一样，饮食摄入很可能是普通人群接触PCDEs的主要途径。然而，关于食品中PCDE水平的数据非常有限。得出的结论是，对PCDEs的实验毒性、饮食摄入和对人体健康的潜在影响进行调查显然是必要的。
