化脓性链球菌临床分离株中erm(A)上游衰减子区域的DNA序列差异及其与大环内酯类/林可酰胺类耐药性的相关性。
Differences in the DNA sequences in the upstream attenuator region of erm(A) in clinical isolates of Streptococcus pyogenes and their correlation with macrolide/lincosamide resistance.
作者信息
Doktor Stella Z, Shortridge Virginia
机构信息
Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA.
出版信息
Antimicrob Agents Chemother. 2005 Jul;49(7):3070-2. doi: 10.1128/AAC.49.7.3070-3072.2005.
Abstract
The regulatory regions of 52 erm(A) [formerly erm(TR)] clinical Streptococcus pyogenes isolates were studied. Differences in the upstream regulatory region of erm(A) correlated with macrolide/lincosamide resistance patterns. Nine macrolide/lincosamide/streptogramin B-resistant isolates had changes in the leader sequence of erm(A) including base changes, insertions, or deletions. Isolates were also emm typed.
摘要
对52株临床化脓性链球菌erm(A) [原erm(TR)]分离株的调控区域进行了研究。erm(A)上游调控区域的差异与大环内酯类/林可酰胺类耐药模式相关。9株对大环内酯类/林可酰胺类/链阳菌素B耐药的分离株在erm(A)的前导序列中有变化，包括碱基变化、插入或缺失。分离株也进行了emm分型。
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