• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

化脓性链球菌临床分离株中erm(A)上游衰减子区域的DNA序列差异及其与大环内酯类/林可酰胺类耐药性的相关性。

Differences in the DNA sequences in the upstream attenuator region of erm(A) in clinical isolates of Streptococcus pyogenes and their correlation with macrolide/lincosamide resistance.

作者信息

Doktor Stella Z, Shortridge Virginia

机构信息

Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3070-2. doi: 10.1128/AAC.49.7.3070-3072.2005.

DOI:10.1128/AAC.49.7.3070-3072.2005
PMID:15980403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1168635/
Abstract

The regulatory regions of 52 erm(A) [formerly erm(TR)] clinical Streptococcus pyogenes isolates were studied. Differences in the upstream regulatory region of erm(A) correlated with macrolide/lincosamide resistance patterns. Nine macrolide/lincosamide/streptogramin B-resistant isolates had changes in the leader sequence of erm(A) including base changes, insertions, or deletions. Isolates were also emm typed.

摘要

对52株临床化脓性链球菌erm(A) [原erm(TR)]分离株的调控区域进行了研究。erm(A)上游调控区域的差异与大环内酯类/林可酰胺类耐药模式相关。9株对大环内酯类/林可酰胺类/链阳菌素B耐药的分离株在erm(A)的前导序列中有变化，包括碱基变化、插入或缺失。分离株也进行了emm分型。

相似文献

1
Differences in the DNA sequences in the upstream attenuator region of erm(A) in clinical isolates of Streptococcus pyogenes and their correlation with macrolide/lincosamide resistance.化脓性链球菌临床分离株中erm(A)上游衰减子区域的DNA序列差异及其与大环内酯类/林可酰胺类耐药性的相关性。
Antimicrob Agents Chemother. 2005 Jul;49(7):3070-2. doi: 10.1128/AAC.49.7.3070-3072.2005.
2
Unusual resistance patterns in macrolide-resistant Streptococcus pyogenes harbouring erm(A).携带erm(A)的耐大环内酯类化脓性链球菌中的异常耐药模式
J Antimicrob Chemother. 2009 Jan;63(1):42-6. doi: 10.1093/jac/dkn432. Epub 2008 Oct 24.
3
A study on erm(B)-mediated MLS resistance in Streptococcus pyogenes clinical isolates. erm(B)介导的酿脓链球菌临床分离株 MLS 耐药性研究。
Diagn Microbiol Infect Dis. 2011 Jul;70(3):387-94. doi: 10.1016/j.diagmicrobio.2011.03.017.
4
Plasmid-Borne erm(T) from invasive, macrolide-resistant Streptococcus pyogenes strains.侵袭性、耐大环内酯类化脓性链球菌菌株中质粒携带的erm(T)
Antimicrob Agents Chemother. 2008 Mar;52(3):1140-3. doi: 10.1128/AAC.01352-07. Epub 2008 Jan 7.
5
Identification and characterization of plasmid-borne erm(T) macrolide resistance in group B and group A Streptococcus.鉴定和表征 B 群和 A 群链球菌中质粒携带的 erm(T)大环内酯类耐药基因。
Diagn Microbiol Infect Dis. 2011 Nov;71(3):217-23. doi: 10.1016/j.diagmicrobio.2011.07.010. Epub 2011 Sep 6.
6
mef(A) is the predominant macrolide resistance determinant in Streptococcus pneumoniae and Streptococcus pyogenes in Germany.mef(A) 是德国肺炎链球菌和化脓性链球菌中主要的大环内酯类耐药决定因素。
Int J Antimicrob Agents. 2011 May;37(5):425-31. doi: 10.1016/j.ijantimicag.2011.01.019. Epub 2011 Mar 21.
7
Ketolide resistance in Streptococcus pyogenes correlates with the degree of rRNA dimethylation by Erm.化脓性链球菌对酮内酯类药物的耐药性与Erm介导的rRNA甲基化程度相关。
Mol Microbiol. 2005 Oct;58(2):613-22. doi: 10.1111/j.1365-2958.2005.04863.x.
8
Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes.由ermTR介导的消化链球菌属对大环内酯类的耐药性：化脓性链球菌中可能的大环内酯-林可酰胺-链阳菌素B耐药性来源。
Antimicrob Agents Chemother. 2001 Feb;45(2):630-2. doi: 10.1128/AAC.45.2.630-632.2001.
9
Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area.从波士顿地区患者中检测出多种对大环内酯类和林可酰胺类耐药的化脓性链球菌菌株。
J Clin Microbiol. 2004 Apr;42(4):1559-63. doi: 10.1128/JCM.42.4.1559-1563.2004.
10
Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era.疫苗接种前时代肺炎链球菌临床分离株中大环内酯类耐药性的演变。
Diagn Microbiol Infect Dis. 2008 Apr;60(4):393-8. doi: 10.1016/j.diagmicrobio.2007.10.020. Epub 2008 Feb 20.

引用本文的文献

1
The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.抗生素抗性甲基转移酶的表达与mRNA稳定性相关，与核糖体停滞无关。
Antimicrob Agents Chemother. 2016 Nov 21;60(12):7178-7188. doi: 10.1128/AAC.01806-16. Print 2016 Dec.
2
Resistance to Macrolide Antibiotics in Public Health Pathogens.公共卫生病原体对大环内酯类抗生素的耐药性
Cold Spring Harb Perspect Med. 2016 Oct 3;6(10):a025395. doi: 10.1101/cshperspect.a025395.
3
New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae.肺炎链球菌中携带红霉素抗性决定簇erm(TR)的新型遗传元件。
Antimicrob Agents Chemother. 2008 Feb;52(2):619-25. doi: 10.1128/AAC.01081-07. Epub 2007 Dec 10.

本文引用的文献

1
Comparison of emm typing and ribotyping with three restriction enzymes to characterize clinical isolates of Streptococcus pyogenes.用三种限制性内切酶对化脓性链球菌临床分离株进行emm分型和核糖体分型的比较，以对其进行特征分析。
J Clin Microbiol. 2005 Jan;43(1):150-5. doi: 10.1128/JCM.43.1.150-155.2005.
2
Molecular analysis of constitutively expressed erm(C) genes selected in vitro by incubation in the presence of the noninducers quinupristin, telithromycin, or ABT-773.通过在无诱导剂的奎奴普丁、泰利霉素或ABT - 773存在下孵育，对体外选择的组成型表达erm(C)基因进行分子分析。
Microb Drug Resist. 2002 Fall;8(3):171-7. doi: 10.1089/107662902760326878.
3
Comparison of in vitro activities of ABT-773 and telithromycin against macrolide-susceptible and -resistant streptococci and staphylococci.ABT-773与泰利霉素对大环内酯类敏感及耐药链球菌和葡萄球菌的体外活性比较。
Antimicrob Agents Chemother. 2002 Mar;46(3):783-6. doi: 10.1128/AAC.46.3.783-786.2002.
4
In vitro selection of resistance to clindamycin related to alterations in the attenuator of the erm(TR) gene of Streptococcus pyogenes UCN1 inducibly resistant to erythromycin.化脓性链球菌UCN1对红霉素诱导耐药，体外筛选与erm(TR)基因弱化子改变相关的克林霉素耐药性。
J Antimicrob Chemother. 2001 Sep;48(3):411-6. doi: 10.1093/jac/48.3.411.
5
Structural alterations in the translational attenuator of constitutively expressed erm(A) genes in Staphylococcus aureus.金黄色葡萄球菌中组成型表达的erm(A)基因翻译弱化子的结构改变。
Antimicrob Agents Chemother. 2001 May;45(5):1603-4. doi: 10.1128/AAC.45.5.1603-1604.2001.
6
Molecular analysis of the translational attenuator of a constitutively expressed erm(A) gene from Staphylococcus intermedius.中间葡萄球菌组成型表达erm(A)基因翻译弱化子的分子分析
J Antimicrob Chemother. 2000 Nov;46(5):785-8. doi: 10.1093/jac/46.5.785.
7
Prevalence of macrolide resistance mechanisms in Streptococcus pneumoniae isolates from a multicenter antibiotic resistance surveillance study conducted in the United States in 1994-1995.1994 - 1995年在美国进行的一项多中心抗生素耐药性监测研究中肺炎链球菌分离株大环内酯类耐药机制的流行情况。
Clin Infect Dis. 1999 Nov;29(5):1186-8. doi: 10.1086/313452.
8
Structural alterations in the translational attenuator of constitutively expressed ermC genes.组成型表达的ermC基因翻译弱化子中的结构改变。
Antimicrob Agents Chemother. 1999 Jul;43(7):1681-5. doi: 10.1128/AAC.43.7.1681.
9
A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes.化脓性链球菌中的一种新型红霉素抗性甲基化酶基因（ermTR）。
Antimicrob Agents Chemother. 1998 Feb;42(2):257-62. doi: 10.1128/AAC.42.2.257.
10
Novel mechanism of macrolide resistance in Streptococcus pneumoniae.肺炎链球菌大环内酯类耐药的新机制。
Diagn Microbiol Infect Dis. 1996 Oct;26(2):73-8. doi: 10.1016/s0732-8893(96)00183-6.