由ermTR介导的消化链球菌属对大环内酯类的耐药性：化脓性链球菌中可能的大环内酯-林可酰胺-链阳菌素B耐药性来源。
Macrolide resistance in Peptostreptococcus spp. mediated by ermTR: possible source of macrolide-lincosamide-streptogramin B resistance in Streptococcus pyogenes.
作者信息
Reig M, Galan J, Baquero F, Perez-Diaz J C
机构信息
Department of Microbiology, Ramón y Cajal Hospital, National Institute of Health (INSALUD), 28034 Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2001 Feb;45(2):630-2. doi: 10.1128/AAC.45.2.630-632.2001.
Abstract
Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptostreptococcus magnus to macrolide-susceptible S. pyogenes strains indicates that this resistance determinant may circulate among gram-positive aerobic and anaerobic species of the oropharyngeal bacterial flora.
摘要
在研究的对大环内酯类耐药的消化链球菌菌株中，80%（26株中的21株）携带ermTR基因。这种甲基转移酶基因也是在对大环内酯类-林可酰胺类-链阳菌素B耐药的化脓性链球菌菌株中最常发现的基因。ermTR基因从大消化链球菌转移至对大环内酯类敏感的化脓性链球菌菌株表明，这种耐药决定簇可能在口咽细菌菌群的革兰氏阳性需氧菌和厌氧菌之间传播。
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