化脓性链球菌中的一种新型红霉素抗性甲基化酶基因（ermTR）。
A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes.
作者信息
Seppälä H, Skurnik M, Soini H, Roberts M C, Huovinen P
机构信息
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
出版信息
Antimicrob Agents Chemother. 1998 Feb;42(2):257-62. doi: 10.1128/AAC.42.2.257.
Abstract
Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, which results in coresistance to macrolide, lincosamide, and streptogramin B antibiotics (MLSB resistance). Genes belonging to the ermAM (ermB) gene class are the only erythromycin resistance methylase (erm) genes in Streptococcus pyogenes with MLSB resistance that have been sequenced so far. We identified a novel erm gene, designated ermTR, from an erythromycin-resistant clinical strain of S. pyogenes (strain A200) with an inducible type of MLSB resistance. The nucleotide sequence of ermTR is 82.5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes.
摘要
链球菌中的红霉素耐药性通常是由于一种rRNA甲基化酶导致的靶位点修饰，这会导致对大环内酯类、林可酰胺类和链阳菌素B抗生素产生交叉耐药性（MLSB耐药性）。属于ermAM（ermB）基因类别的基因是化脓性链球菌中迄今已测序的唯一具有MLSB耐药性的红霉素耐药甲基化酶（erm）基因。我们从一株具有诱导型MLSB耐药性的化脓性链球菌红霉素耐药临床菌株（A200菌株）中鉴定出一个新的erm基因，命名为ermTR。ermTR的核苷酸序列与之前在金黄色葡萄球菌和凝固酶阴性葡萄球菌中发现的ermA有82.5%的同源性。我们的发现首次提供了化脓性链球菌中除ermAM之外介导MLSB耐药性的erm基因序列。
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