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RACE:基因表达数据的远程分析计算

RACE: Remote Analysis Computation for gene Expression data.

作者信息

Psarros Michael, Heber Steffen, Sick Manuela, Thoppae Gnanasekaran, Harshman Keith, Sick Beate

机构信息

DNA Array Facility, Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.

出版信息

Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W638-43. doi: 10.1093/nar/gki490.

Abstract

The Remote Analysis Computation for gene Expression data (RACE) suite is a collection of bioinformatics web tools designed for the analysis of DNA microarray data. RACE performs probe-level data preprocessing, extensive quality checks, data visualization and data normalization for Affymetrix GeneChips. In addition, it offers differential expression analysis on normalized expression levels from any array platform. RACE estimates the false discovery rates of lists of potentially regulated genes and provides a Gene Ontology-term analysis tool for GeneChip data to support the biological interpretation and annotation of results. The analysis is fully automated but can be customized by flexible parameter settings. To offer a convenient starting point for subsequent analyses, and to provide maximum transparency, the R scripts used to generate the results can be downloaded along with the output files. RACE is freely available for use at http://race.unil.ch.

摘要

基因表达数据远程分析计算(RACE)套件是一组生物信息学网络工具,旨在分析DNA微阵列数据。RACE对Affymetrix基因芯片进行探针级数据预处理、广泛的质量检查、数据可视化和数据归一化。此外,它还能对来自任何阵列平台的归一化表达水平进行差异表达分析。RACE估计潜在调控基因列表的错误发现率,并为基因芯片数据提供基因本体术语分析工具,以支持结果的生物学解释和注释。该分析完全自动化,但可通过灵活的参数设置进行定制。为了为后续分析提供便利的起点,并提供最大的透明度,用于生成结果的R脚本可与输出文件一起下载。可在http://race.unil.ch免费使用RACE。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11ad/1160250/9e098a388ec2/gki490f1.jpg

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