克罗恩病中的分枝杆菌情况
The mycobacteria story in Crohn's disease.
作者信息
Shanahan Fergus, O'Mahony Jim
出版信息
Am J Gastroenterol. 2005 Jul;100(7):1537-8. doi: 10.1111/j.1572-0241.2005.50358.x.
Abstract
The heterogeneity of Crohn's disease suggests that it would be unwise to dismiss an infectious contribution to the pathogenesis in a subset of patients. The most enduring infectious candidate has been Mycobacterium paratuberculosis, which appears to be widespread in nature and appears to have the potential to infect humans. However, there are many counterarguments to the notion that MAP causes Crohn's disease, and numerous observations are seemingly at variance with this concept.
摘要
克罗恩病的异质性表明，忽视感染因素在一部分患者发病机制中的作用是不明智的。最具持久性的感染候选病原体是副结核分枝杆菌，它在自然界似乎广泛存在，且似乎有感染人类的潜力。然而，关于副结核分枝杆菌导致克罗恩病这一观点存在许多反对意见，众多观察结果似乎也与这一概念不符。
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