鸟分枝杆菌副结核亚种、克罗恩病的遗传易感性与撒丁岛人：未来之路
Mycobacterium avium subsp. paratuberculosis, genetic susceptibility to Crohn's disease, and Sardinians: the way ahead.
作者信息
Sechi Leonardo A, Gazouli Maria, Ikonomopoulos John, Lukas John C, Scanu Antonio M, Ahmed Niyaz, Fadda Giovanni, Zanetti Stefania
机构信息
Dipartimento di Scienze Biomediche, Sezione di Microbiologia Sperimentale e Clinica, Università degli Studi di Sassari, Viale S. Pietro 43/B, 07100 Sassari, Italy.
出版信息
J Clin Microbiol. 2005 Oct;43(10):5275-7. doi: 10.1128/JCM.43.10.5275-5277.2005.
Abstract
The present study was performed to determine what proportion of people in Sardinia with or without Crohn's disease were infected with Mycobacterium avium subspecies paratuberculosis and had a preponderance of allelic variants of Nod 2, an intracellular protein involved in Crohn's disease susceptibility. Genetic analysis of the alleles of the NOD 2/CARD 15 gene (ins C 3020, G 908 R, and R 702 W alleles), linked to susceptibility or genetic predisposition to Crohn's disease in humans, was carried out on specimens from 37 Crohn's disease patients and 34 patients without Crohn's disease. Our results show that more than 70 percent of people in Sardinia with Crohn's disease carry at least one of the susceptibility-associated NOD 2/CARD 15 alleles and were infected with Mycobacterium avium subspecies paratuberculosis.
摘要
本研究旨在确定撒丁岛患有或未患克罗恩病的人群中，感染副结核分枝杆菌鸟亚种且携带与克罗恩病易感性相关的细胞内蛋白Nod 2等位基因变体占优势的比例。对37例克罗恩病患者和34例非克罗恩病患者的样本进行了NOD 2/CARD 15基因（插入C 3020、G 908 R和R 702 W等位基因）等位基因的遗传分析，这些等位基因与人类克罗恩病的易感性或遗传易感性相关。我们的结果表明，撒丁岛超过70%的克罗恩病患者携带至少一种与易感性相关的NOD 2/CARD 15等位基因，并且感染了副结核分枝杆菌鸟亚种。
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