兔抗EL4血清。一种可区分小鼠细胞毒性细胞和抑制性细胞的试剂。

Rabbit anti-EL4 serum. A reagent which discriminates between murine cytotoxic and suppressor cells.

作者信息

Al-Sakkaf L, Cooke A, Heppel L, Hutchings P, Jones B

出版信息

Immunology. 1979 Nov;38(3):609-12.

PMID:42615

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457840/

Abstract

Antisera against the C57B1 (H-2b) mouse lymphoma, EL4, were prepared in rabbits. After absorption with mouse liver, red cells and thymocytes, the antisera appeared to be cytotoxic for a subpopulation of peripheral T cells. The absorbed antisera blocked the immunosuppressive function observed when spleen cells from mice undergoing a graft versus host reaction were added to cells responding in vitro to sheep erythrocytes. This antiserum was unreactive against the cytotoxic cells also induced in this system. These results substantiate our previous finding that these antisera are specific for T-suppressor as opposed to T-helper or cytotoxic lymphocyte subpopulations.

摘要

针对C57B1（H-2b）小鼠淋巴瘤EL4制备了兔抗血清。用小鼠肝脏、红细胞和胸腺细胞吸收后，该抗血清对一部分外周T细胞具有细胞毒性。吸收后的抗血清阻断了在移植物抗宿主反应的小鼠脾细胞加入到体外对绵羊红细胞产生反应的细胞时所观察到的免疫抑制功能。该抗血清对该系统中诱导产生的细胞毒性细胞无反应。这些结果证实了我们之前的发现，即这些抗血清对T抑制细胞具有特异性，而非针对T辅助细胞或细胞毒性淋巴细胞亚群。

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J Exp Med. 1971 Jul 1;134(1):103-19. doi: 10.1084/jem.134.1.103.

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J Exp Med. 1976 Aug 1;144(2):330-44. doi: 10.1084/jem.144.2.330.

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