Pickles M J, Joiner A, Weader E, Cooper Y L, Cox T F
Unilever Oral Care, Port Sunlight Laboratory, Bebington, Wirral, UK.
Int Dent J. 2005;55(3 Suppl 1):188-93. doi: 10.1111/j.1875-595x.2005.tb00058.x.
To determine the rates of enamel and dentine wear in situ during tooth brushing with a range of five toothpastes of differing RDA and REA values.
Enamel/dentine inserts were placed in the buccal aspects of full upper dentures of human volunteers. Enamel wear was determined by change in Knoop indent length and dentine wear was determined from the enamel-dentine step height, measured using optical profilometry.
Significant differences between the test products were found for both enamel and dentine (p < 0.05). However for the conventional toothpastes the rate of wear was similar and differences between the products were not generally statistically significant for either enamel or dentine, despite the fact that their RDA values differed by more than a factor of two. The rate of wear was found to decrease throughout the duration of the study.
The study demonstrated that the methodology used is capable of assessing enamel and dentine wear in situ within a relatively short period of time. The data suggest that whilst in vitro tests have value in understanding differences in abrasivity between products, they cannot be used to predict in vivo effects.
使用一系列具有不同磨损率数值(RDA)和相对磨损率数值(REA)的五种牙膏刷牙时,测定牙釉质和牙本质的原位磨损率。
将牙釉质/牙本质嵌体置于人类志愿者全口上颌假牙的颊侧。牙釉质磨损通过努氏压痕长度的变化来确定,牙本质磨损通过牙釉质-牙本质台阶高度来确定,使用光学轮廓仪进行测量。
在牙釉质和牙本质方面,测试产品之间均存在显著差异(p < 0.05)。然而,对于传统牙膏,磨损率相似,尽管其磨损率数值相差两倍多,但产品之间在牙釉质或牙本质方面的差异通常无统计学意义。在整个研究期间,磨损率均呈下降趋势。
该研究表明,所使用的方法能够在相对较短的时间内评估牙釉质和牙本质的原位磨损。数据表明,虽然体外测试在理解产品之间磨蚀性差异方面具有价值,但它们不能用于预测体内效果。