Romero-Jiménez Magdalena, Campos-Sánchez Juan, Analla Mohamed, Muñoz-Serrano Andrés, Alonso-Moraga Angeles
University of Cordoba, Department of Genetics, Campus Universitario Rabanales, Edificio Gregor Mendel, C-5, 14071 Cordoba, Spain.
Mutat Res. 2005 Aug 1;585(1-2):147-55. doi: 10.1016/j.mrgentox.2005.05.004.
Six herbal infusions used worldwide (Matricaria chamomilla, Tilia cordata, Mentha piperita, Mentha pulegium, Uncaria tomentosa and Valeriana officinalis) were assayed for anti-genotoxicity using the Somatic Mutation And Recombination Test (SMART) in Drosophila melanogaster. All these infusions are traditionally used for various medical purposes, including anti-inflammatory processes. Hydrogen peroxide was used as an oxidative genotoxicant to test the anti-genotoxic potency of the medicinal infusions. None of these infusions showed a significant genotoxicity, quite the reverse they were able to behave as desmutagens, detoxifying the mutagen hydrogen peroxide. The phenolic content of such herbal infusions is argued to be the possible scavenger of reactive oxygen radicals produced by the hydrogen peroxide.
使用果蝇的体细胞突变和重组试验（SMART），对全球范围内使用的六种草药浸剂（洋甘菊、心叶椴、胡椒薄荷、唇萼薄荷、猫爪草和缬草）进行了抗基因毒性测定。所有这些浸剂传统上都用于各种医疗目的，包括抗炎过程。过氧化氢被用作氧化基因毒性剂，以测试药用浸剂的抗基因毒性效力。这些浸剂均未显示出明显的基因毒性，相反，它们能够起到抗诱变剂的作用，对诱变剂过氧化氢进行解毒。据认为，此类草药浸剂中的酚类成分可能是过氧化氢产生的活性氧自由基的清除剂。
