Uno Tomoko, Ohsawa Isao, Tokudome Mizuho, Sato Yuzo
Department of Metabolism and Endocrinology, Internal Medicine, Labor Welfare Corporation, Chubu Rosai Hospital, Komei 1-10-6, Minato-ku, Nagoya 455-8530, Japan.
Diabetes Res Clin Pract. 2005 Aug;69(2):129-35. doi: 10.1016/j.diabres.2004.11.017.
We investigated the effects of Goshajinkigan (GJG), a Chinese herbal medicine, on insulin sensitivity in patients with type 2 diabetes using the homeostasis model assessment of insulin resistance (HOMA-R) and the euglycemic insulin clamp procedure. Daily oral administration of GJG (7.5 g/day) was performed for 1 month in 71 type 2 diabetes patients: the GJG treatment group. HOMA-Rs were calculated before and after 1 month of GJG treatment and compared with those of 44 controls who were matched in terms of sex, age, body mass index (BMI) and HbA1c levels with the experimental group. In 64 patients out of the GJG treatment group, HOMA-R was calculated 1 month after discontinuation of treatment. In addition, euglycemic clamp was conducted in eight patients before and after the GJG treatment. HOMA-R was 4.78+/-0.37 (means+/-S.E.) before GJG treatment and significantly decreased to 4.02+/-0.25 after GJG treatment (P=0.019). No significant change was observed in the control group. HOMA-R returned to the pre-treatment level (P=0.018) 1 month after GJG treatment discontinuation. Glucose infusion rates and metabolic clearance rates determined by the high-dose euglycemic clamp increased after 1 month of GJG treatment (from 9.6+/-1.1 to 11.1+/-0.7 mg/kg/min, P=0.045 and from 7.9+/-0.8 to 9.1+/-0.8 ml/kg/min, P=0.046, respectively). These results indicate that GJG administration might be useful for improving insulin resistance in patients with type 2 diabetes.
我们使用胰岛素抵抗稳态模型评估（HOMA-R）和正常血糖胰岛素钳夹术，研究了中药桂枝茯苓丸（GJG）对2型糖尿病患者胰岛素敏感性的影响。71例2型糖尿病患者（GJG治疗组）每日口服GJG（7.5克/天），持续1个月。在GJG治疗1个月前后计算HOMA-R，并与44名在性别、年龄、体重指数（BMI）和糖化血红蛋白水平方面与实验组匹配的对照组患者的HOMA-R进行比较。GJG治疗组中的64例患者在停药1个月后计算HOMA-R。此外，在8例患者中于GJG治疗前后进行了正常血糖钳夹试验。GJG治疗前HOMA-R为4.78±0.37（均值±标准误），治疗后显著降至4.02±0.25（P = 0.019）。对照组未观察到显著变化。GJG治疗停药1个月后，HOMA-R恢复到治疗前水平（P = 0.018）。GJG治疗1个月后，高剂量正常血糖钳夹试验测定的葡萄糖输注率和代谢清除率增加（分别从9.6±1.1增至11.1±0.7毫克/千克/分钟，P = 0.045；从7.9±0.8增至9.1±0.8毫升/千克/分钟，P = 0.046）。这些结果表明，服用GJG可能有助于改善2型糖尿病患者的胰岛素抵抗。
