Park Mi Hwa, Nam Young Hwa, Han Ji-Sook
Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736, Korea.
Department of Food Science and Nutrition, Pusan National University, Busan 609-735, Korea.
Nutr Res Pract. 2015 Oct;9(5):472-9. doi: 10.4162/nrp.2015.9.5.472. Epub 2015 Jun 19.
BACKGROUND/OBJECTIVES: The goal of this study was to examine the effect of Sargassum coreanum extract (SCE) on blood glucose concentration and insulin resistance in C57BL-KsJ-db/db mice.
MATERIALS/METHODS: For 6 weeks, male C57BL/KsJ-db/db mice were administrated SCE (0.5%, w/w), and rosiglitazone (0.005%, w/w).
A supplement of the SCE for 6 weeks induced a significant reduction in blood glucose and glycosylated hemoglobin concentrations, and it improved hyperinsulinemia compared to the diabetic control db/db mice. The glucokinase activity in the hepatic glucose metabolism increased in the SCE-supplemented db/db mice, while phosphoenolpyruvate carboxykinase and glucose-6-phosphatase activities in the SCE-supplemented db/db mice were significantly lower than those in the diabetic control db/db mice. The homeostatic index of insulin resistance was lower in the SCE-supplemented db/db mice than in the diabetic control db/db mice.
These results suggest that a supplement of the SCE lowers the blood glucose concentration by altering the hepatic glucose metabolic enzyme activities and improves insulin resistance.
背景/目的：本研究旨在探讨半叶马尾藻提取物（SCE）对C57BL-KsJ-db/db小鼠血糖浓度和胰岛素抵抗的影响。
材料/方法：雄性C57BL/KsJ-db/db小鼠连续6周给予SCE（0.5%，w/w）和罗格列酮（0.005%，w/w）。
与糖尿病对照db/db小鼠相比，补充SCE 6周可显著降低血糖和糖化血红蛋白浓度，并改善高胰岛素血症。补充SCE的db/db小鼠肝脏葡萄糖代谢中的葡萄糖激酶活性增加，而补充SCE的db/db小鼠中的磷酸烯醇丙酮酸羧激酶和葡萄糖-6-磷酸酶活性显著低于糖尿病对照db/db小鼠。补充SCE的db/db小鼠的胰岛素抵抗稳态指数低于糖尿病对照db/db小鼠。
这些结果表明，补充SCE可通过改变肝脏葡萄糖代谢酶活性降低血糖浓度并改善胰岛素抵抗。
