School of Engineering, University of California, San Diego La Jolla, CA 92093, USA.
Lab Chip. 2017 May 16;17(10):1834-1842. doi: 10.1039/c7lc00192d.
The demand for wearable sensors has grown rapidly in recent years, with increasing attention being given to epidermal chemical sensing. Here, we present the first example of a fully integrated eyeglasses wireless multiplexed chemical sensing platform capable of real-time monitoring of sweat electrolytes and metabolites. The new concept has been realized by integrating an amperometric lactate biosensor and a potentiometric potassium ion-selective electrode into the two nose-bridge pads of the glasses and interfacing them with a wireless electronic backbone placed on the glasses' arms. Simultaneous real-time monitoring of sweat lactate and potassium levels with no apparent cross-talk is demonstrated along with wireless signal transduction. The electrochemical sensors were screen-printed on polyethylene terephthalate (PET) stickers and placed on each side of the glasses' nose pads in order to monitor sweat metabolites and electrolytes. The electronic backbone on the arms of the glasses' frame offers control of the amperometric and potentiometric transducers and enables Bluetooth wireless data transmission to the host device. The new eyeglasses system offers an interchangeable-sensor feature in connection with a variety of different nose-bridge amperometric and potentiometric sensor stickers. For example, the lactate bridge-pad sensor was replaced with a glucose one to offer convenient monitoring of sweat glucose. Such a fully integrated wireless "Lab-on-a-Glass" multiplexed biosensor platform can be readily expanded for the simultaneous monitoring of additional sweat electrolytes and metabolites.
近年来，对可穿戴传感器的需求迅速增长，人们越来越关注表皮化学传感。在这里，我们提出了第一个完全集成的眼镜式无线多路复用化学传感平台的示例，该平台能够实时监测汗液中的电解质和代谢物。通过将安培乳酸生物传感器和电位钾离子选择性电极集成到眼镜的两个鼻梁垫中，并将其与放置在眼镜臂上的无线电子主干接口，实现了这一新概念。同时，还演示了无线信号传输时，无明显串扰的实时监测汗液中乳酸和钾离子水平的情况。电化学传感器通过丝网印刷在聚对苯二甲酸乙二醇酯 (PET) 不干胶上，并放置在眼镜鼻垫的每一侧，以监测汗液中的代谢物和电解质。眼镜框架臂上的电子主干提供了对安培计和电位计传感器的控制，并实现了与主机设备的蓝牙无线数据传输。新的眼镜系统提供了一种可互换传感器的功能，可与各种不同的鼻梁桥接安培计和电位计传感器不干胶配合使用。例如，可以用葡萄糖传感器替换乳酸桥接垫传感器，以便方便地监测汗液中的葡萄糖。这种完全集成的无线“玻璃上的实验室”多路复用生物传感器平台可以很容易地扩展到同时监测其他汗液电解质和代谢物。
