RNA干扰：RNA诱导沉默复合体的基本原理
RNAi: the nuts and bolts of the RISC machine.
作者信息
Filipowicz Witold
机构信息
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
出版信息
Cell. 2005 Jul 15;122(1):17-20. doi: 10.1016/j.cell.2005.06.023.
PMID:16009129
Abstract
Research on RNA interference and microRNA pathways continues to accelerate. Combinations of biochemical, genetic, and structural approaches are providing new insights into the mechanism by which small, approximately 21 nt long RNAs find their way into the RISC effector complexes and how the RISCs execute their mission of RNA-guided posttranscriptional gene silencing.
摘要
RNA干扰和微小RNA途径的研究仍在加速进行。生物化学、遗传学和结构学方法的结合，正为小分子（约21个核苷酸长）RNA进入RNA诱导沉默复合体（RISC）效应复合物的机制，以及RISC如何执行其RNA引导的转录后基因沉默任务提供新的见解。
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