Zhang Yahui, Jin Zhaoxia, Liu Linxia, Zhang Dawei
School of Biological Engineering, Dalian Polytechnic University, Dalian 116034, China.
Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China.
Microorganisms. 2025 Apr 17;13(4):927. doi: 10.3390/microorganisms13040927.
Metabolic engineering has a wide range of applications, spanning key sectors such as energy, pharmaceuticals, agriculture, chemicals, and environmental sustainability. Its core focus is on precisely modulating metabolic pathways to achieve efficient, sustainable, and environmentally friendly biomanufacturing processes, offering new possibilities for societal sustainable development. Gene attenuation is a critical technique within metabolic engineering, pivotal in optimizing metabolic fluxes and improving target metabolite yields. This review article discusses gene attenuation mechanisms, the applications across various biological systems, and implementation strategies. Additionally, we address potential future challenges and explore its potential to drive further advancements in the field.
代谢工程有广泛的应用，涵盖能源、制药、农业、化工和环境可持续性等关键领域。其核心重点是精确调节代谢途径，以实现高效、可持续和环境友好的生物制造过程，为社会可持续发展提供新的可能性。基因衰减是代谢工程中的一项关键技术，对优化代谢通量和提高目标代谢物产量至关重要。这篇综述文章讨论了基因衰减机制、在各种生物系统中的应用以及实施策略。此外，我们还探讨了未来潜在的挑战，并探索其推动该领域进一步发展的潜力。
