葫芦素和葫芦烷糖苷：结构与生物活性。
Cucurbitacins and cucurbitane glycosides: structures and biological activities.
作者信息
Chen Jian Chao, Chiu Ming Hua, Nie Rui Lin, Cordell Geoffrey A, Qiu Samuel X
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, Yunnan, P.R. China.
出版信息
Nat Prod Rep. 2005 Jun;22(3):386-99. doi: 10.1039/b418841c. Epub 2005 Apr 4.
The natural cucurbitacins constitute a group of triterpenoid substances which are well-known for their bitterness and toxicity. Structurally, they are characterized by the tetracyclic cucurbitane nucleus skeleton, namely, 19-(10-->9beta)-abeo-10alpha-lanost-5-ene (also known as 9beta-methyl-19-norlanosta-5-ene), with a variety of oxygen substitutions at different positions. According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered.
天然葫芦素是一类三萜类物质，以其苦味和毒性而闻名。在结构上，它们的特征是具有四环葫芦烷核骨架，即19-(10→9β)-去甲-10α-羊毛甾-5-烯（也称为9β-甲基-19-降羊毛甾-5-烯），在不同位置有多种氧取代。根据其结构特点，葫芦素可分为十二类。文中还介绍了葫芦素的生物学效应。
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