Siraj Fouzia, Kaur Manveen, Dalal Varsha, Khanna Ashima, Khan Afaq Ahmad
National Institute of Pathology, ICMR, Safdarjung Hospital Campus, New Delhi, India.
JLNM Hospital, Srinagar, India.
Ger Med Sci. 2017 Feb 9;15:Doc03. doi: 10.3205/000244. eCollection 2017.
Myeloid sarcoma (MS) or granulocytic sarcoma is a rare tumor consisting of myeloid blasts with or without maturation occurring at anatomic sites other than the bone marrow. MS can involve any organ system but shows a predilection for skin, bone, and soft tissues of head and neck region. We report four cases of MS occurring at unusual sites, out of which three were de novo and one was associated with acute myeloid leukemia (AML). Although MS is associated with AML, it can rarely present without any existent hematologic disease. Differential diagnosis of a soft tissue mass should include MS even in the absence of leukemia. Establishment of the correct diagnosis depends on morphologic, histochemical, and immunohistochemical examination.
髓系肉瘤（MS）或粒细胞肉瘤是一种罕见肿瘤，由骨髓母细胞组成，可伴有或不伴有成熟，发生于骨髓以外的解剖部位。MS可累及任何器官系统，但好发于皮肤、骨骼以及头颈部软组织。我们报告了4例发生于不寻常部位的MS，其中3例为原发性，1例与急性髓系白血病（AML）相关。虽然MS与AML相关，但它很少在没有任何现存血液系统疾病的情况下出现。即使在没有白血病的情况下，软组织肿块的鉴别诊断也应包括MS。正确诊断的确立取决于形态学、组织化学和免疫组织化学检查。
