非胰岛素依赖型糖尿病患者的血浆非胆固醇甾醇

Plasma non-cholesterol sterols in patients with non-insulin dependent diabetes mellitus.

作者信息

Sutherland W H, Scott R S, Lintott C J, Robertson M C, Stapely S A, Cox C

机构信息

Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.

出版信息

Horm Metab Res. 1992 Apr;24(4):172-5. doi: 10.1055/s-2007-1003287.

DOI:10.1055/s-2007-1003287

PMID:1601392

Abstract

Plasma plant sterol concentrations (an index of cholesterol absorption efficiency) and plasma lathosterol concentration (an index of cholesterol synthesis rate) were measured in 52 patients with non-insulin dependent diabetes mellitus (NIDDM) and 36 non-diabetic controls. Plasma plant sterol concentrations were significantly (P less than 0.01) lower in diabetic patients (campesterol: men -36%, women -48%; betasitosterol: men -35%, women -42%). Fasting serum insulin levels were inversely correlated with plasma plant sterol concentrations in diabetic patients (campesterol: r = -0.347, P = 0.012; betasitosterol: r = -0.345, P = 0.012) and in non-diabetic men (campesterol: r = -0.578, P = 0.039; betasitosterol: r = -0.702, P = 0.008). Serum insulin levels were also correlated significantly with plasma lathosterol concentration in diabetic patients (r = 0.295, P = 0.034). The results of this study suggest that absorption of plant sterols and possibly cholesterol from the diet may be reduced in hyperinsulinemic diabetics.

摘要

对52例非胰岛素依赖型糖尿病（NIDDM）患者和36例非糖尿病对照者测定了血浆植物甾醇浓度（胆固醇吸收效率指标）和血浆羊毛甾醇浓度（胆固醇合成速率指标）。糖尿病患者的血浆植物甾醇浓度显著降低（P<0.01）（菜油甾醇：男性降低36%，女性降低48%；β-谷甾醇：男性降低35%，女性降低42%）。糖尿病患者空腹血清胰岛素水平与血浆植物甾醇浓度呈负相关（菜油甾醇：r = -0.347，P = 0.012；β-谷甾醇：r = -0.345，P = 0.012），非糖尿病男性也是如此（菜油甾醇：r = -0.578, P = 0.039；β-谷甾醇：r = -0.702, P = 0.008）。糖尿病患者血清胰岛素水平与血浆羊毛甾醇浓度也显著相关（r = 0.295，P = 0.034）。本研究结果提示，高胰岛素血症的糖尿病患者从饮食中吸收植物甾醇以及可能还有胆固醇的能力可能会降低。