Sutherland W H, Robertson M C, Williamson S A, Nye E R
Department of Medicine, University of Otago Medical School, Dunedin, New Zealand.
Eur J Appl Physiol Occup Physiol. 1991;63(2):119-23. doi: 10.1007/BF00235180.
Plasma lathosterol concentration is taken to be an index of the rate of cholesterol synthesis and plasma concentrations of plant sterols just as campesterol and betasitosterol are taken to be indeces of cholesterol absorption efficiency. These noncholesterol sterols were measured in plasma from 14 male distance runners and 10 sedentary men. Plasma lathosterol concentration was 30% lower (P less than 0.02) and plasma betasitosterol concentration was 33% higher (P less than 0.02) in the runners compared to the sedentary men. Plasma concentrations of lathosterol and plant sterols were inversely and significantly (P less than 0.05) correlated in both the runners and the sedentary men. Plasma plant sterol concentrations were correlated positively and significantly (P less than 0.01) with plasma high density lipoprotein cholesterol (HDL-C) concentrations in the runners and sedentary men combined. These findings suggest that more efficient cholesterol absorption may lead to higher plasma plant sterol concentrations and may contribute to lower cholesterol synthesis rates, reduced concentrations of plasma lathosterol and higher plasma HDL-C concentration in distance runners.
血浆羊毛甾醇浓度被视为胆固醇合成速率的指标，而血浆植物甾醇（如菜油甾醇和β-谷甾醇）的浓度则被视为胆固醇吸收效率的指标。对14名男性长跑运动员和10名久坐男性的血浆进行了这些非胆固醇甾醇的测量。与久坐男性相比，长跑运动员的血浆羊毛甾醇浓度低30%（P<0.02），血浆β-谷甾醇浓度高33%（P<0.02）。长跑运动员和久坐男性的血浆羊毛甾醇和植物甾醇浓度均呈显著负相关（P<0.05）。将长跑运动员和久坐男性合并后，血浆植物甾醇浓度与血浆高密度脂蛋白胆固醇（HDL-C）浓度呈显著正相关（P<0.01）。这些发现表明，更有效的胆固醇吸收可能导致血浆植物甾醇浓度升高，并可能导致长跑运动员的胆固醇合成速率降低、血浆羊毛甾醇浓度降低以及血浆HDL-C浓度升高。
