Tapia Milagritos D, Sow Samba O, Medina-Moreno Sandra, Lim Yu, Pasetti Marcela F, Kotloff Karen, Levine Myron M
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Am J Trop Med Hyg. 2005 Jul;73(1):26-31.
As infants lose maternally derived antibody, they experience a period when antibody levels are insufficient to protect against measles yet may interfere with immunization. In Kangaba Mali, sera were collected from 89 2-8-month-old infants and 32 9-10-month-old infants without a history of measles or vaccination; post-vaccination sera were collected from 24 of the 9-10-month-old infants 3-5 weeks after receiving measles vaccine. Measles antibody was measured by plaque reduction neutralization (PRN) and enzyme linked immunosorbent assay. At two months of age, 30% had protective PRN titers; among six-month-old infants, none had protective titers. Prior to vaccination, 16% of 9-10-month-old infants exhibited protective titers; all demonstrated protective titers post-vaccination. The early onset of the window of vulnerability in Kangaba infants likely reflects the changing ecology of measles in Africa. Ways to protect these vulnerable infants against measles must be devised.
随着婴儿失去母体来源的抗体，他们会经历一段抗体水平不足以预防麻疹但可能干扰免疫接种的时期。在马里的坎加巴，从89名2至8个月大且无麻疹病史或未接种过疫苗的婴儿以及32名9至10个月大的婴儿中采集血清；在9至10个月大的婴儿中，有24名在接种麻疹疫苗3至5周后采集了接种后血清。通过蚀斑减少中和试验（PRN）和酶联免疫吸附测定法检测麻疹抗体。在两个月大时，30%的婴儿具有保护性PRN滴度；在六个月大的婴儿中，无人具有保护性滴度。在接种疫苗前，9至10个月大的婴儿中有16%表现出保护性滴度；接种疫苗后所有人都表现出保护性滴度。坎加巴婴儿易感染期的早期出现可能反映了非洲麻疹生态环境的变化。必须想出保护这些易感染婴儿免受麻疹侵害的方法。
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