Cuijpers P
Department of Clinical Psychology, Vrije Universiteit Amsterdam, The Netherlands.
Aging Ment Health. 2005 Jul;9(4):325-30. doi: 10.1080/13607860500090078.
Although depressive symptomatology has been well studied in caregivers of patients with dementia, depressive disorders have been examined much less. We conducted a systematic literature search in major bibliographical databases (Medline, Psychinfo, Dissertation Abstracts), and included studies examining caregivers of dementia patients that reported the prevalence of major depressive disorder, according to diagnostic criteria as assessed with a standardized psychiatric diagnostic interview. Ten studies with a total of 790 caregivers were identified (sample sizes: 22-147). In only one of the studies, a representative community sample was used. A total of 176 subjects (22.3%) had a depressive disorder (prevalence range from 0.15-0.32). In the three studies reporting differential prevalence rates for men and women somewhat smaller prevalence rates were found for men than for women. In six studies caregivers were compared to a (mostly matched) control group. The relative risks of having a depressive disorder in caregivers ranged from 2.80-38.68 (all RR's were significant). In the three prospective studies relatively high incidence rates were found (0.48). This study made it clear that prevalence and incidence of depressive disorders are increased in caregivers of dementia patients. More research is clearly needed in this population.
尽管痴呆症患者的照料者的抑郁症状已得到充分研究，但对抑郁症的研究却少得多。我们在主要书目数据库（医学在线数据库、心理学文摘数据库、学位论文摘要数据库）中进行了系统的文献检索，并纳入了那些根据标准化精神科诊断访谈评估的诊断标准来报告重度抑郁症患病率的痴呆症患者照料者研究。共识别出10项研究，涉及790名照料者（样本量：22 - 147）。其中只有一项研究使用了具有代表性的社区样本。共有176名受试者（22.3%）患有抑郁症（患病率范围为0.15 - 0.32）。在三项报告了男性和女性不同患病率的研究中，男性的患病率略低于女性。在六项研究中，照料者与一个（大多匹配的）对照组进行了比较。照料者患抑郁症的相对风险范围为2.80 - 38.68（所有相对风险均具有显著性）。在三项前瞻性研究中发现了相对较高的发病率（0.48）。这项研究表明，痴呆症患者照料者中抑郁症的患病率和发病率有所增加。显然，这一人群还需要更多研究。
