神经节苷脂对实验性变应性神经炎的影响。

Influence of gangliosides on experimental allergic neuritis.

作者信息

Wiethölter H, Schabet M, Stevens A, Melms A, Sommer N, Weller M

机构信息

Department of Neurology, University of Tübingen, FRG.

出版信息

J Neuroimmunol. 1992 Jun;38(3):221-8. doi: 10.1016/0165-5728(92)90015-d.

DOI:10.1016/0165-5728(92)90015-d

PMID:1601979

Abstract

The development of myelin-induced experimental allergic neuritis (EAN) in Lewis rats can be depressed and delayed by adding a ganglioside mixture (GM1, GD1a, GD1b, GT1b) to the immunization compound; however, gangliosides may enhance the induction of adjuvant arthritis. Antibodies against multiple gangliosides are produced in rats after immunization with gangliosides after addition of myelin, but only low titers can be detected in animals immunized with myelin and complete Freund's adjuvant alone. We conclude that this antibody production is not the result of peripheral nerve inflammation but depends rather from external applied gangliosides.

摘要

在免疫复合物中添加神经节苷脂混合物（GM1、GD1a、GD1b、GT1b）可抑制和延缓Lewis大鼠髓磷脂诱导的实验性变应性神经炎（EAN）的发展；然而，神经节苷脂可能会增强佐剂性关节炎的诱导。在用髓磷脂添加神经节苷脂免疫大鼠后，会产生针对多种神经节苷脂的抗体，但在用髓磷脂和完全弗氏佐剂单独免疫的动物中只能检测到低滴度抗体。我们得出结论，这种抗体产生不是周围神经炎症的结果，而是取决于外部应用的神经节苷脂。