Ledeen R W, Oderfeld-Nowak B, Brosnan C F, Cervone A
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461.
Ann Neurol. 1990;27 Suppl:S69-74. doi: 10.1002/ana.410270718.
The effect of gangliosides on the clinical course of experimental allergic neuritis was tested in Lewis rats sensitized with bovine intradural root myelin in complete Freund's adjuvant. A mixture of bovine brain gangliosides (GM1, GD1a, GD1b, GT1b) was injected intramuscularly at a daily dose of 20 mg per kilogram of body weight, beginning 6 days after inoculation. The results from seven different experiments show that in most cases, the administered gangliosides were partially protective. Particularly striking was the reduction in mortality rate to half or less of saline-injected controls. Cumulative clinical index scores were also significantly lower with ganglioside treatment in five of the seven experiments. The cause of the wide variability is not known, but it was noted that better results were obtained when the animals were sensitized with freshly isolated myelin.
在用完全弗氏佐剂中的牛硬膜内神经根髓磷脂致敏的Lewis大鼠中，测试了神经节苷脂对实验性变应性神经炎临床病程的影响。从接种后第6天开始，以每千克体重每日20毫克的剂量肌肉注射牛脑神经节苷脂混合物（GM1、GD1a、GD1b、GT1b）。七个不同实验的结果表明，在大多数情况下，给予的神经节苷脂具有部分保护作用。特别显著的是死亡率降低至注射生理盐水对照组的一半或更低。在七个实验中的五个实验中，神经节苷脂治疗组的累积临床指数评分也显著更低。变异性大的原因尚不清楚，但注意到当用新鲜分离的髓磷脂致敏动物时可获得更好的结果。
