Amiez Céline, Joseph Jean-Paul, Procyk Emmanuel
Inserm U371, Cerveau et Vision, Department of Cognitive Neurosciences, IFR19, UCB-Lyon1, 18 av. doyen Lépine, 69500 Bron, France.
Eur J Neurosci. 2005 Jun;21(12):3447-52. doi: 10.1111/j.1460-9568.2005.04170.x.
Learning abilities depend on detection and exploitation of errors. In primates, this function involves the anterior cingulate cortex. However, whether anterior cingulate error-related activity indicates occurrence of inappropriate responses or results from other computations is debated. Here we have tested whether reward-related parameters modulate error-related activity of anterior cingulate neurons. Recordings in monkeys performing stimulus-reward associations and preliminary data obtained with a problem-solving task revealed major properties of error-related unit activity: (i) their amplitude varies with the amount of predicted reward or the proximity to reward delivery; (ii) they appear both after execution and performance errors; (iii) they do not indicate which error occurred or which correction to make; and (iv), importantly, the activity of these neurons also increases following an external signal indicating the necessity to shift response. Hence, we conclude that anterior cingulate 'error' activity might represent a negative deviation from a predicted goal, and does not only reflect error detection but signals events interrupting potentially rewarded actions.
学习能力取决于对错误的检测和利用。在灵长类动物中，这一功能涉及前扣带皮层。然而，前扣带与错误相关的活动是表明出现了不适当的反应还是源于其他计算，目前仍存在争议。在这里，我们测试了与奖励相关的参数是否会调节前扣带神经元与错误相关的活动。对执行刺激-奖励关联任务的猴子进行的记录以及通过解决问题任务获得的初步数据揭示了与错误相关的单位活动的主要特性：（i）它们的幅度随预测奖励的数量或接近奖励交付的程度而变化；（ii）它们在执行错误和表现错误后都会出现；（iii）它们并不表明发生了哪种错误或需要进行哪种纠正；（iv）重要的是，这些神经元的活动在表明需要改变反应的外部信号之后也会增加。因此，我们得出结论，前扣带“错误”活动可能代表与预测目标的负偏差，不仅反映错误检测，还标志着中断潜在奖励行动的事件。
