颠覆发现范式：荧光化学传感器组合发现的新方法。
Reversing the discovery paradigm: a new approach to the combinatorial discovery of fluorescent chemosensors.
作者信息
Mello Jesse V, Finney Nathaniel S
机构信息
Department of Chemistry and Biochemistry, University of California, San Diego 9500 Gilman Drive, La Jolla, California 92093-0358, USA
出版信息
J Am Chem Soc. 2005 Jul 27;127(29):10124-5. doi: 10.1021/ja043682p.
PMID:16028896
Abstract
We report here a new approach to the discovery of fluorescent chemosensors in which a new signaling mechanism allows a core fluorophore to be used in a combinatorial search for new binding events, thus reversing the reigning discovery paradigm.
摘要
我们在此报告一种发现荧光化学传感器的新方法，其中一种新的信号传导机制使得核心荧光团可用于对新结合事件的组合搜索，从而颠覆了现有的发现模式。
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