Thanner F, Sütterlin M W, Kapp M, Rieger L, Morr A K, Kristen P, Dietl J, Gassel A M, Müller Th
Department of Obstetrics and Gynecology, University of Würzburg, Germany.
Anticancer Res. 2005 May-Jun;25(3A):1649-53.
Heat shock protein 27 (hsp27) is a molecular chaperone which supports cells to keep their homeostasis under stressful conditions. It is associated with resistance to chemotherapeutics, radiation and hyperthermia. The aim of this retrospective study was to investigate the prognostic value of hsp27 for patients with node-negative breast cancer.
Paraffin sections of 191 patients were stained immunohistochemically with a monoclonal antibody against hsp27. Median follow-up was 177 months. The results were correlated with clinical and histopathological parameters using the Chi-square test.
There was no significant correlation between hsp27 expression and standard histopathological features or the proliferation marker ki-67. Disease-free survival (DFS) was not altered for patients expressing hsp27-positive tumors, whereas overall survival (OS) [p=0. 02] and survival after first recurrence (SR) [p=0.01] were significantly decreased.
The expression of hsp27 in primary breast cancers is associated with a short survival for node-negative patients.
热休克蛋白27（hsp27）是一种分子伴侣，可支持细胞在应激条件下维持其稳态。它与对化疗、放疗和热疗的抗性相关。这项回顾性研究的目的是调查hsp27对淋巴结阴性乳腺癌患者的预后价值。
用抗hsp27单克隆抗体对191例患者的石蜡切片进行免疫组织化学染色。中位随访时间为177个月。使用卡方检验将结果与临床和组织病理学参数相关联。
hsp27表达与标准组织病理学特征或增殖标志物ki-67之间无显著相关性。hsp27阳性肿瘤患者的无病生存期（DFS）未改变，而总生存期（OS）[p = 0.02]和首次复发后的生存期（SR）[p = 0.01]显著降低。
原发性乳腺癌中hsp27的表达与淋巴结阴性患者的生存期缩短有关。
