van Heijst Jeroen W J, Niessen Hans W M, Hoekman Klaas, Schalkwijk Casper G
Department of Internal Medicine, University Hospital Maastricht, Debeyelaan 25, P.O. Box 5800, 6202 AZ Maastricht, the Netherlands.
Ann N Y Acad Sci. 2005 Jun;1043:725-33. doi: 10.1196/annals.1333.084.
Tumors are generally characterized by an increased glucose uptake and a high rate of glycolysis. Since one consequence of an elevated glycolysis is the nonenzymatic glycation of proteins, we studied the presence of advanced glycation end products (AGEs) in human cancer tissues. We detected the presence of the AGEs N(epsilon)-(carboxymethyl)lysine (CML) and argpyrimidine in several human tumors using specific antibodies. Because AGEs have been associated with the etiology of a variety of different diseases, these results suggest that CML and argpyrimidine could be implicated in the biology of human cancer.
肿瘤通常的特征是葡萄糖摄取增加和糖酵解速率较高。由于糖酵解增强的一个后果是蛋白质的非酶糖基化，我们研究了人类癌症组织中晚期糖基化终产物（AGEs）的存在情况。我们使用特异性抗体在几种人类肿瘤中检测到了AGEs N(ε)-(羧甲基)赖氨酸（CML）和精氨嘧啶的存在。因为AGEs与多种不同疾病的病因有关，这些结果表明CML和精氨嘧啶可能与人类癌症生物学有关。
