Stewart Michael W, Liesegang Thomas J, Schwam Brian L
Department of Ophthalmology, Mayo Clinic College of Medicine, Jacksonville, FL 32082, USA.
Am J Ophthalmol. 2005 Jul;140(1):161-2. doi: 10.1016/j.ajo.2005.01.004.
To report a case of coexistent Chlamydia conjunctivitis and central retinal vein occlusion (CRVO) in which both problems improved significantly after oral doxycyline.
Interventional case report.
A healthy 39-year-old man presented with follicular and papillary conjunctivitis, unresponsive to topical antibiotic therapy, and a CRVO. The patient had serum IgG titers of 1:256 to both Chlamydia pneumonia and Chlamydia trachomatous.
Treatment with oral doxycyline (100 mg orally twice daily for 2 weeks) resulted in complete resolution of the conjunctivitis and rapid improvement of the CRVO.
Because of its ability to cause chronic vascular endothelial infection and localized inflammation, Chlamydia has been implicated in the development of arterial vascular disease. The positive Chlamydia serology, conjunctivitis, CRVO, and excellent response to doxycycline in this patient suggest that Chlamydia may have contributed to his vascular occlusion. Further studies investigating a possible association between Chlamydia and CRVO may be indicated.
报告1例衣原体性结膜炎与视网膜中央静脉阻塞（CRVO）并存的病例，口服强力霉素后这两个问题均有显著改善。
介入性病例报告。
一名39岁健康男性出现滤泡性和乳头性结膜炎，局部抗生素治疗无效，同时患有CRVO。该患者肺炎衣原体和沙眼衣原体的血清IgG滴度均为1:256。
口服强力霉素（100毫克，每日两次，共2周）治疗后，结膜炎完全消退，CRVO迅速改善。
由于衣原体能够引起慢性血管内皮感染和局部炎症，故其与动脉血管疾病的发生有关。该患者衣原体血清学阳性、结膜炎、CRVO以及对强力霉素的良好反应表明，衣原体可能导致了其血管阻塞。可能需要进一步研究来探讨衣原体与CRVO之间的潜在关联。
