衣原体抗体与前列腺癌风险
Chlamydial antibodies and risk of prostate cancer.
作者信息
Anttila Tarja, Tenkanen Leena, Lumme Sonja, Leinonen Maija, Gislefoss Randi Elin, Hallmans Göran, Thoresen Steinar, Hakulinen Timo, Luostarinen Tapio, Stattin Pär, Saikku Pekka, Dillner Joakim, Lehtinen Matti, Hakama Matti
机构信息
National Public Health Institute, Oulu, Finland.
出版信息
Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):385-9. doi: 10.1158/1055-9965.EPI-03-0325.
OBJECTIVE
We assessed the risk of prostate cancer by exposure to Chlamydia trachomatis.
METHOD
Seven hundred thirty eight cases of prostate cancer and 2,271 matched controls were identified from three serum sample banks in Finland, Norway, and Sweden by linkage to the population based cancer registries.
RESULTS
A statistically significant inverse association (odds ratio, 0.69; 95% confidence interval, 0.51-0.94) was found. It was consistent by different serotypes and there was a consistent dose-response relationship.
CONCLUSION
C. trachomatis infection is not likely to increase the risk of prostate cancer. Whether the inverse relationship is true or due to difficulties in measuring the true exposure in prostatic tissue by serology, confounders or other sources of error remain open.
目的
我们评估了沙眼衣原体暴露与前列腺癌风险之间的关系。
方法
通过与基于人群的癌症登记处建立联系，从芬兰、挪威和瑞典的三个血清样本库中确定了738例前列腺癌病例和2271例匹配对照。
结果
发现了具有统计学意义的负相关（比值比，0.69；95%置信区间，0.51 - 0.94）。不同血清型之间结果一致，且存在一致的剂量反应关系。
结论
沙眼衣原体感染不太可能增加前列腺癌风险。这种负相关关系是真实存在还是由于通过血清学测量前列腺组织中真实暴露情况存在困难、混杂因素或其他误差来源所致，仍有待探讨。
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