Engelhardt Britta, Ransohoff Richard M
Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland.
Trends Immunol. 2005 Sep;26(9):485-95. doi: 10.1016/j.it.2005.07.004.
This review addresses current knowledge of the molecular trafficking signals involved in the migration of circulating leukocytes across the highly specialized blood-central nervous system (CNS) barriers during immunosurveillance and inflammation. In this regard, adhesion molecules and activating and chemotactic factors are also discussed and the regional variability in the brain and spinal cord parenchyma are also considered. Furthermore, direct passage into cerebrospinal fluid (CSF) is discussed, in the context of CNS immunosurveillance. The potential differences that characterize leukocyte entry into these varied anatomical sites are highlighted, with special emphasis on studies of the pathogenesis of multiple sclerosis and its animal models. An update on findings from clinical trials of natalizumab is also provided.
本综述阐述了当前关于免疫监视和炎症期间循环白细胞穿越高度特化的血脑屏障和血脊髓屏障迁移所涉及的分子运输信号的知识。就此，还讨论了黏附分子、激活因子和趋化因子，并考虑了脑和脊髓实质的区域变异性。此外，在中枢神经系统免疫监视的背景下讨论了直接进入脑脊液（CSF）的情况。突出了白细胞进入这些不同解剖部位所具有的潜在差异，特别强调了对多发性硬化症及其动物模型发病机制的研究。还提供了那他珠单抗临床试验结果的最新情况。
