Sathyanarayanan P V, Poovaiah B W
Center for Integrated Biotechnology, Washington State University, Pullman, WA 99164-6414, USA.
CRC Crit Rev Plant Sci. 2004;23(1):1-11. doi: 10.1080/07352680490273310.
Different input signals create their own characteristic Ca2+ fingerprints. These fingerprints are distinguished by frequency, amplitude, duration, and number of Ca2+ oscillations. Ca(2+)-binding proteins and protein kinases decode these complex Ca2+ fingerprints through conformational coupling and covalent modifications of proteins. This decoding of signals can lead to a physiological response with or without changes in gene expression. In plants, Ca(2+)-dependent protein kinases and Ca2+/calmodulin-dependent protein kinases are involved in decoding Ca2+ signals into phosphorylation signals. This review summarizes the elements of conformational coupling and molecular mechanisms of regulation of the two groups of protein kinases by Ca2+ and Ca2+/calmodulin in plants.
不同的输入信号会产生各自独特的钙离子指纹。这些指纹通过钙离子振荡的频率、幅度、持续时间和数量来区分。钙离子结合蛋白和蛋白激酶通过蛋白质的构象偶联和共价修饰来解读这些复杂的钙离子指纹。这种信号解读可导致生理反应，无论基因表达有无变化。在植物中，钙离子依赖型蛋白激酶和钙离子/钙调素依赖型蛋白激酶参与将钙离子信号解码为磷酸化信号。本综述总结了植物中钙离子和钙离子/钙调素对这两类蛋白激酶的构象偶联要素及调控分子机制。
