Sikka Rishi, Xia Fang, Aubert Ronald E
Department of Medical Affairs, Medco Health Solutions, Franklin Lakes, NJ 07417, USA.
Am J Manag Care. 2005 Jul;11(7):449-57.
To review the definitions and methods for measuring medication persistency, and to propose a uniform definition of and calculation for persistency using pharmacy claims data.
Literature review.
A MEDLINE search (1966 to present) was performed to identify articles detailing a definition or method of persistency measurement based on automated pharmacy data. Articles were screened for relevance by title and abstract. References from identified articles were used to expand the search results.
The concept behind medication persistency measurement is to capture the amount of time that an individual remains on chronic drug therapy. The methods to calculate medication persistency can be classified into 1 of 3 categories: (1) Persistency as a function of the medication possession ratio; (2) persistency as a function of medication availability at a fixed point in time; and (3) persistency as a function of the gaps between refills.
The common goal of all persistency measures should be to reflect the continuity of medication usage and to capture the timeliness and the frequency of refilling. The measurement of persistency as a function of the gaps between refills provides the best assessment of refill compliance across a variety of medication and disease states and lends itself to the well-established measurements of survival analysis.
回顾药物持续性的定义和测量方法，并提出使用药房报销数据对持续性进行统一的定义和计算方法。
文献综述。
进行了一次MEDLINE检索（1966年至今），以识别详细阐述基于自动化药房数据的持续性测量定义或方法的文章。通过标题和摘要筛选文章的相关性。利用已识别文章的参考文献来扩展检索结果。
药物持续性测量背后的概念是获取个体接受慢性药物治疗的时长。计算药物持续性的方法可分为以下三类之一：（1）持续性作为药物持有率的函数；（2）持续性作为固定时间点药物可获得性的函数；（3）持续性作为续方间隔的函数。
所有持续性测量的共同目标应是反映药物使用的连续性，并获取续方的及时性和频率。将持续性作为续方间隔的函数进行测量，能对各种药物和疾病状态下的续方依从性提供最佳评估，并且适用于生存分析中成熟的测量方法。
