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德国首例耐泰利霉素肺炎链球菌分离株的分子特征分析

Molecular characterization of the first telithromycin-resistant Streptococcus pneumoniae isolate in Germany.

作者信息

Reinert Ralf René, van der Linden Mark, Al-Lahham Adnan

机构信息

Institute for Medical Microbiology, National Reference Center for Streptococci, University Hospital, Pauwelsstrasse 30, D-52057 Aachen, Germany.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3520-2. doi: 10.1128/AAC.49.8.3520-3522.2005.

DOI:10.1128/AAC.49.8.3520-3522.2005
PMID:16048973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196262/
Abstract

A total of 486 Streptococcus pneumoniae isolates were collected in 2003 and 2004 in Germany and revealed the following resistance rates: penicillin G (7.2%) and erythromycin A (18.9%). Telithromycin exhibited good in vitro activity (MIC at which 90% of the isolates tested were inhibited, 0.125 microg/ml). However, one erm(B)-positive isolate was found to be telithromycin resistant (MIC, 8 microg/ml).

摘要

2003年和2004年在德国共收集了486株肺炎链球菌分离株，其耐药率如下：青霉素G（7.2%）和红霉素A（18.9%）。替利霉素表现出良好的体外活性（90%受试分离株被抑制时的最低抑菌浓度，0.125微克/毫升）。然而，发现一株erm(B)阳性分离株对替利霉素耐药（最低抑菌浓度，8微克/毫升）。

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Activities of telithromycin against 13,874 Streptococcus pneumoniae isolates collected between 1999 and 2003.泰利霉素对1999年至2003年间收集的13874株肺炎链球菌的活性。
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Ribosomal mutations conferring resistance to macrolides in Streptococcus pneumoniae clinical strains isolated in Germany.在德国分离出的肺炎链球菌临床菌株中赋予对大环内酯类抗生素耐药性的核糖体突变。
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