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本文引用的文献

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Caspofungin resistance in Candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis.白色念珠菌对卡泊芬净的耐药性：将临床结果与从一名进行性念珠菌食管炎患者连续获得的三株同基因分离株的实验室药敏试验相关联。
Antimicrob Agents Chemother. 2004 Apr;48(4):1382-3. doi: 10.1128/AAC.48.4.1382-1383.2004.
2
Combination antifungal therapy.联合抗真菌治疗。
Antimicrob Agents Chemother. 2004 Mar;48(3):693-715. doi: 10.1128/AAC.48.3.693-715.2004.
3
Guidelines for treatment of candidiasis.念珠菌病治疗指南。
Clin Infect Dis. 2004 Jan 15;38(2):161-89. doi: 10.1086/380796. Epub 2003 Dec 19.
4
Combination antifungal therapy against Candida species: the new frontier--are we there yet?针对念珠菌属的联合抗真菌治疗：新前沿——我们到那儿了吗？
Med Mycol. 2003 Oct;41(5):355-68. doi: 10.1080/13693780310001616528.
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In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolates.卡泊芬净与氟康唑和伊曲康唑相比，对3959株念珠菌属临床分离株（包括157株氟康唑耐药分离株）的体外活性。
Antimicrob Agents Chemother. 2003 Mar;47(3):1068-71. doi: 10.1128/AAC.47.3.1068-1071.2003.
6
Trends in antifungal susceptibility of Candida spp. isolated from pediatric and adult patients with bloodstream infections: SENTRY Antimicrobial Surveillance Program, 1997 to 2000.1997年至2000年从患有血流感染的儿科和成人患者中分离出的念珠菌属的抗真菌药敏趋势：SENTRY抗菌监测计划
J Clin Microbiol. 2002 Mar;40(3):852-6. doi: 10.1128/JCM.40.3.852-856.2002.
7
Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after the adoption of prophylactic fluconazole.异基因造血干细胞移植受者的念珠菌血症：采用氟康唑预防后的危险因素演变
J Infect Dis. 2000 Jan;181(1):309-16. doi: 10.1086/315193.
8
Natural defenses against Candida colonization breakdown in the oral cavities of the elderly.老年人口腔中针对念珠菌定植的天然防御机制出现瓦解。
J Dent Res. 1999 Apr;78(4):857-68. doi: 10.1177/00220345990780040601.
9
Current and emerging azole antifungal agents.当前及新出现的唑类抗真菌药物。
Clin Microbiol Rev. 1999 Jan;12(1):40-79. doi: 10.1128/CMR.12.1.40.
10
Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation.在一名接受骨髓移植的患者中，引起播散性感染的白色念珠菌对氟康唑产生耐药性的情况。
Clin Infect Dis. 1997 Oct;25(4):908-10. doi: 10.1086/515553.

泊沙康唑与卡泊芬净对光滑念珠菌临床分离株的体外相互作用

In vitro interaction of posaconazole and caspofungin against clinical isolates of Candida glabrata.

作者信息

Oliveira E R, Fothergill A W, Kirkpatrick W R, Coco B J, Patterson T F, Redding S W

机构信息

Department of General Dentistry, University of Texas Health Science Center at San Antonio, Mail Code 7914, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

出版信息

Antimicrob Agents Chemother. 2005 Aug;49(8):3544-5. doi: 10.1128/AAC.49.8.3544-3545.2005.

DOI:10.1128/AAC.49.8.3544-3545.2005
PMID:16048980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1196222/
Abstract

Combinations of caspofungin and posaconazole were evaluated by fractional inhibitory concentration index against 119 Candida glabrata isolates. Synergy was seen in 18% of all isolates and in 4% of fluconazole-resistant isolates at 48 h without evidence of antagonism. This antifungal combination may have utility against this organism.

摘要

通过部分抑菌浓度指数对119株光滑念珠菌分离株评估了卡泊芬净和泊沙康唑的联合作用。在48小时时，所有分离株中有18%出现协同作用，氟康唑耐药分离株中有4%出现协同作用，且无拮抗证据。这种抗真菌联合用药可能对该病原体有效。