Ruan Sheng-Yuan, Chu Chen-Chen, Hsueh Po-Ren
Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.
Antimicrob Agents Chemother. 2008 Aug;52(8):2919-22. doi: 10.1128/AAC.00323-08. Epub 2008 May 5.
Voriconazole, posaconazole, caspofungin, micafungin, and anidulafungin demonstrated potent in vitro activities against 286 invasive Candida isolates. Analysis of the fluconazole susceptibilities of 204 bloodstream Candida glabrata isolates revealed a rapid shift from susceptible (64% in 1999 to 2001 to 19% in 2007) to susceptible-dose dependent (27% in 1999 to 2001 and 75% in 2007).
伏立康唑、泊沙康唑、卡泊芬净、米卡芬净和阿尼芬净对286株侵袭性念珠菌分离株显示出强大的体外活性。对204株光滑念珠菌血流感染分离株的氟康唑敏感性分析显示,其敏感性迅速从敏感(1999年至2001年为64%,2007年为19%)转变为剂量依赖性敏感(1999年至2001年为27%,2007年为75%)。