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Posaconazole activity against Candida glabrata after exposure to caspofungin or amphotericin B.泊沙康唑在暴露于卡泊芬净或两性霉素B后对光滑念珠菌的活性。
Antimicrob Agents Chemother. 2008 Feb;52(2):513-7. doi: 10.1128/AAC.01447-07. Epub 2007 Dec 3.
2
In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance.念珠菌属侵袭性分离株对阿尼芬净、卡泊芬净和米卡芬净的体外敏感性：六年全球监测
J Clin Microbiol. 2008 Jan;46(1):150-6. doi: 10.1128/JCM.01901-07. Epub 2007 Nov 21.
3
Results from the ARTEMIS DISK Global Antifungal Surveillance study, 1997 to 2005: an 8.5-year analysis of susceptibilities of Candida species and other yeast species to fluconazole and voriconazole determined by CLSI standardized disk diffusion testing.1997年至2005年ARTEMIS DISK全球抗真菌监测研究结果：一项对念珠菌属及其他酵母菌种对氟康唑和伏立康唑敏感性的8.5年分析，采用CLSI标准化纸片扩散法检测。
J Clin Microbiol. 2007 Jun;45(6):1735-45. doi: 10.1128/JCM.00409-07. Epub 2007 Apr 18.
4
Epidemiology of invasive candidiasis: a persistent public health problem.侵袭性念珠菌病的流行病学：一个持续存在的公共卫生问题。
Clin Microbiol Rev. 2007 Jan;20(1):133-63. doi: 10.1128/CMR.00029-06.
5
In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts.泊沙康唑、氟康唑、伊曲康唑、伏立康唑和两性霉素B对大量临床重要霉菌和酵母菌的体外活性。
Antimicrob Agents Chemother. 2006 Jun;50(6):2009-15. doi: 10.1128/AAC.00163-06.
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Clinical significance of azole antifungal drug cross-resistance in Candida glabrata.光滑念珠菌中唑类抗真菌药物交叉耐药的临床意义
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Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing.氟康唑与念珠菌的解释性折点再探讨：抗真菌药敏试验未来的蓝图。
Clin Microbiol Rev. 2006 Apr;19(2):435-47. doi: 10.1128/CMR.19.2.435-447.2006.
8
Phenotypic switching in Candida lusitaniae on copper sulfate indicator agar: association with amphotericin B resistance and filamentation.葡萄牙念珠菌在硫酸铜指示琼脂上的表型转换：与两性霉素B耐药性及丝状化的关联
J Clin Microbiol. 2006 Apr;44(4):1536-9. doi: 10.1128/JCM.44.4.1536-1539.2006.
9
Correlation of MIC with outcome for Candida species tested against voriconazole: analysis and proposal for interpretive breakpoints.针对念珠菌属对伏立康唑的药敏试验，最小抑菌浓度（MIC）与结果的相关性分析及解释性折点建议
J Clin Microbiol. 2006 Mar;44(3):819-26. doi: 10.1128/JCM.44.3.819-826.2006.
10
Head-to-head comparison of the activities of currently available antifungal agents against 3,378 Spanish clinical isolates of yeasts and filamentous fungi.目前可用抗真菌药物对3378株西班牙临床分离酵母和丝状真菌活性的直接比较。
Antimicrob Agents Chemother. 2006 Mar;50(3):917-21. doi: 10.1128/AAC.50.3.917-921.2006.

念珠菌属侵袭性分离株的体外药敏情况：氟康唑敏感剂量依赖性光滑念珠菌分离株的比例迅速上升。

In vitro susceptibilities of invasive isolates of Candida species: rapid increase in rates of fluconazole susceptible-dose dependent Candida glabrata isolates.

作者信息

Ruan Sheng-Yuan, Chu Chen-Chen, Hsueh Po-Ren

机构信息

Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan.

出版信息

Antimicrob Agents Chemother. 2008 Aug;52(8):2919-22. doi: 10.1128/AAC.00323-08. Epub 2008 May 5.

DOI:10.1128/AAC.00323-08
PMID:18458136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2493111/
Abstract

Voriconazole, posaconazole, caspofungin, micafungin, and anidulafungin demonstrated potent in vitro activities against 286 invasive Candida isolates. Analysis of the fluconazole susceptibilities of 204 bloodstream Candida glabrata isolates revealed a rapid shift from susceptible (64% in 1999 to 2001 to 19% in 2007) to susceptible-dose dependent (27% in 1999 to 2001 and 75% in 2007).

摘要

伏立康唑、泊沙康唑、卡泊芬净、米卡芬净和阿尼芬净对286株侵袭性念珠菌分离株显示出强大的体外活性。对204株光滑念珠菌血流感染分离株的氟康唑敏感性分析显示，其敏感性迅速从敏感（1999年至2001年为64%，2007年为19%）转变为剂量依赖性敏感（1999年至2001年为27%，2007年为75%）。