卡泊芬净对氟康唑耐药念珠菌临床分离株的活性。
Caspofungin activity against clinical isolates of fluconazole-resistant Candida.
作者信息
Pfaller Michael A, Messer Shawn A, Boyken Linda, Rice Cassie, Tendolkar Shailesh, Hollis Richard J, Diekema Daniel J
机构信息
Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA.
出版信息
J Clin Microbiol. 2003 Dec;41(12):5729-31. doi: 10.1128/JCM.41.12.5729-5731.2003.
Abstract
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).
摘要
共对7837株念珠菌临床分离株进行了氟康唑药敏试验，鉴定出351株耐药（氟康唑MIC≥64μg/ml）菌株（占总检测菌株的4%）。所有氟康唑耐药菌株均被卡泊芬净抑制，其浓度可被标准剂量超过（90%菌株被抑制时的MIC为1μg/ml；99%的MIC≤2μg/ml）。
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