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Variation in susceptibility of bloodstream isolates of Candida glabrata to fluconazole according to patient age and geographic location.光滑念珠菌血流分离株对氟康唑的敏感性随患者年龄和地理位置的变化情况。
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In vitro activities of voriconazole, posaconazole, and four licensed systemic antifungal agents against Candida species infrequently isolated from blood.伏立康唑、泊沙康唑及四种已获许可的全身用抗真菌药对从血液中罕见分离出的念珠菌属的体外活性。
J Clin Microbiol. 2003 Jan;41(1):78-83. doi: 10.1128/JCM.41.1.78-83.2003.
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Secular trend of hospital-acquired candidemia among intensive care unit patients in the United States during 1989-1999.1989 - 1999年美国重症监护病房患者医院获得性念珠菌血症的长期趋势。
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Epidemiology of candidemia: 3-year results from the emerging infections and the epidemiology of Iowa organisms study.念珠菌血症的流行病学：来自爱荷华州新兴感染与微生物流行病学研究的3年结果。
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卡泊芬净对氟康唑耐药念珠菌临床分离株的活性。

Caspofungin activity against clinical isolates of fluconazole-resistant Candida.

作者信息

Pfaller Michael A, Messer Shawn A, Boyken Linda, Rice Cassie, Tendolkar Shailesh, Hollis Richard J, Diekema Daniel J

机构信息

Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA.

出版信息

J Clin Microbiol. 2003 Dec;41(12):5729-31. doi: 10.1128/JCM.41.12.5729-5731.2003.

DOI:10.1128/JCM.41.12.5729-5731.2003
PMID:14662968
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC309007/
Abstract

A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).

摘要

共对7837株念珠菌临床分离株进行了氟康唑药敏试验，鉴定出351株耐药（氟康唑MIC≥64μg/ml）菌株（占总检测菌株的4%）。所有氟康唑耐药菌株均被卡泊芬净抑制，其浓度可被标准剂量超过（90%菌株被抑制时的MIC为1μg/ml；99%的MIC≤2μg/ml）。