Tucker M A, Shields J A, Hartge P, Augsburger J, Hoover R N, Fraumeni J F
N Engl J Med. 1985 Sep 26;313(13):789-92. doi: 10.1056/NEJM198509263131305.
In a case-control study, we compared 444 patients with intraocular malignant melanoma with matched controls to evaluate the role of exposure to ultraviolet radiation and other risk factors in the pathogenesis of this tumor. Persons born in the southern United States had a relative risk of 2.7 (95 per cent confidence interval, 1.3 to 5.9) as compared with those born in the North. Subjects with brown eyes were protected as compared with those with blue eyes (relative risk, 0.6; 95 per cent confidence interval, 0.4 to 0.8), but complexion and hair color were not important risk factors. Patients with intraocular malignant melanoma were also more likely to have spent time outdoors in their gardens, to have sunbathed, and to have used sunlamps. Rarely wearing hats, visors, or sunglasses while in the sun was a risk factor for the disease (relative risk, 1.9; 95 per cent confidence interval, 1.6 to 2.2). These data suggest that sunlight exposure is an important risk factor for intraocular melanoma.
在一项病例对照研究中，我们将444例眼内恶性黑色素瘤患者与匹配的对照组进行比较，以评估紫外线辐射暴露及其他危险因素在该肿瘤发病机制中的作用。与出生在美国北部的人相比，出生在美国南部的人的相对风险为2.7（95%置信区间为1.3至5.9）。与蓝眼睛的人相比，棕色眼睛的人受到了保护（相对风险为0.6；95%置信区间为0.4至0.8），但肤色和发色并非重要的危险因素。眼内恶性黑色素瘤患者也更有可能花时间在自家花园里户外活动、进行日光浴以及使用太阳灯。在阳光下很少戴帽子、帽舌或太阳镜是该疾病的一个危险因素（相对风险为1.9；95%置信区间为1.6至2.2）。这些数据表明，阳光暴露是眼内黑色素瘤的一个重要危险因素。
