衰老对同源功能及免疫记忆发育的影响。
The effect of aging on cognate function and development of immune memory.
作者信息
Haynes Laura
机构信息
Trudeau Institute, Saranac Lake, New York 12983, USA.
出版信息
Curr Opin Immunol. 2005 Oct;17(5):476-9. doi: 10.1016/j.coi.2005.07.003.
Abstract
Immunological memory is one of the central features of the immune system and can be described as the ability of the immune system to respond more efficiently to a second encounter with the same pathogen. The immune system is dramatically affected by age-related changes and it is becoming apparent that immune memory exhibits significant defects as a result of aging. Although immune memory generated during youth functions well into old age, that generated later in life functions poorly. Importantly, age-related defects in the cognate helper function of CD4(+) T cells can potentially influence the development of both humoral and cell-mediated immune memory. These defects ultimately result in aged individuals who exhibit reduced responses to both infections and vaccinations.
摘要
免疫记忆是免疫系统的核心特征之一，可被描述为免疫系统在再次遇到相同病原体时更高效作出反应的能力。免疫系统会受到与年龄相关变化的显著影响，并且越来越明显的是，免疫记忆因衰老而表现出明显缺陷。尽管年轻时产生的免疫记忆在老年时仍能良好发挥作用，但晚年产生的免疫记忆功能较差。重要的是，CD4(+) T细胞同源辅助功能中与年龄相关的缺陷可能会潜在影响体液免疫和细胞介导免疫记忆的发展。这些缺陷最终导致老年个体对感染和疫苗接种的反应均降低。
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