Dursunoglu D, Dursunoglu N, Evrengül H, Ozkurt S, Kuru O, Kiliç M, Fisekci F
Dept of Cardiology, University Medical Faculty, Denizli, Turkey.
Eur Respir J. 2005 Aug;26(2):283-8. doi: 10.1183/09031936.05.00038804.
Obstructive sleep apnoea syndrome (OSAS) might be a cause of heart failure. The present study aimed to assess left ventricular mass and myocardial performance index (MPI) in OSAS patients. A total of 67 subjects without any cardiac or pulmonary disease, referred for evaluation of OSAS, had overnight polysomnography and echocardiography. According to apnoea-hypopnoea index (AHI), subjects were classified into three groups: mild OSAS (AHI: 5-14; n = 16), moderate OSAS (AHI: 15-29; n = 18), and severe OSAS (AHI: > or = 30; n = 33). Thickness of interventricular septum (IVS) and posterior wall (LVPW) were measured by M-mode, along with left ventricular mass (LVM) and LVM index (LVMI). Left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Döppler echocardiography. There were no differences in age or body mass index among the groups, but blood pressures were higher in severe OSAS compared with moderate and mild OSAS. In severe OSAS, thickness of IVS (11.2+/-1.1 mm), LVPW (11.4+/-0.9 mm), LVM (298.8+/-83.1 g) and LVMI (144.7+/-39.8 g x m(-2)) were higher than in moderate OSAS (10.9+/-1.3 mm; 10.8+/-0.9 mm; 287.3+/-74.6 g; 126.5+/-41.2 g x m(-2), respectively) and mild OSAS (9.9+/-0.9 mm; 9.8+/-0.8 mm; 225.6+/-84.3 g; 100.5+/-42.3 g x m(-2), respectively). In severe OSAS, MPI (0.64+/-0.14) was significantly higher than in mild OSAS (0.50+/-0.09), but not significantly higher than moderate OSAS (0.60+/-0.10). In conclusion, severe and moderate obstructive sleep apnoea syndrome patients had higher left ventricular mass and left ventricular mass index, and also left ventricular global dysfunction.
阻塞性睡眠呼吸暂停综合征（OSAS）可能是心力衰竭的一个原因。本研究旨在评估OSAS患者的左心室质量和心肌性能指数（MPI）。共有67名无任何心脏或肺部疾病、因OSAS评估前来就诊的受试者接受了夜间多导睡眠图和超声心动图检查。根据呼吸暂停低通气指数（AHI），受试者被分为三组：轻度OSAS（AHI：5 - 14；n = 16）、中度OSAS（AHI：15 - 29；n = 18）和重度OSAS（AHI：≥30；n = 33）。通过M型超声测量室间隔（IVS）和后壁（LVPW）厚度，以及左心室质量（LVM）和左心室质量指数（LVMI）。通过多普勒超声心动图计算左心室MPI，公式为（等容收缩时间 + 等容舒张时间）/主动脉射血时间。各组间年龄或体重指数无差异，但重度OSAS患者的血压高于中度和轻度OSAS患者。在重度OSAS患者中，IVS厚度（11.2±1.1 mm）、LVPW厚度（11.4±0.9 mm）、LVM（298.8±83.1 g）和LVMI（144.7±39.8 g·m⁻²）高于中度OSAS患者（分别为10.9±1.3 mm；10.8±0.9 mm；287.3±74.6 g；126.5±41.2 g·m⁻²）和轻度OSAS患者（分别为9.9±0.9 mm；9.8±0.8 mm；225.6±84.3 g；100.5±42.3 g·m⁻²）。在重度OSAS患者中，MPI（0.64±0.14）显著高于轻度OSAS患者（0.50±0.09），但高于中度OSAS患者（0.60±0.10）的差异不显著。总之，重度和中度阻塞性睡眠呼吸暂停综合征患者的左心室质量和左心室质量指数较高，且存在左心室整体功能障碍。
