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[氯喹引起的眼部毒性:病例报告]

[Ocular toxicity caused by chloroquine: case report].

作者信息

Inada Eliane Terumi, Watanabe Karina Paula, Tanaka Sérgio Gustavo, Sakakisbara Luís Antônio

机构信息

Faculdade de Medicina, São José do Rio Preto, Brazil.

出版信息

Arq Bras Oftalmol. 2005 May-Jun;68(3):407-9. doi: 10.1590/s0004-27492005000300027. Epub 2005 Jul 26.

Abstract

To report a case of ocular toxicity due to chloroquine. The best visual acuity was measured in both eyes with the Snellen chart. Slit-lamp examination of anterior segment, refraction, dilated fundus examination, fluorescein angiography and retinography was done in a 53-year-old patient, female, with rheumatoid arthritis. She had used chloroquine during 6 years and had stopped for 1 year when she came to our service. She had best corrected visual acuity of 20/200 and 20/40. Slit-lamp examination showed intraocular lens in right eye and nuclear cataract (1+/4) in the other, and bilateral corneal subepithelial opacity inferior to the visual axis. Fundus examination showed macular area with retinal pigment epithelium atrophy. Fluorescein angiography showed a bull's eye maculopathy. Report of a typical keratopathy and maculopathy caused by chloroquine.

摘要

报告一例因氯喹导致的眼部毒性病例。使用斯内伦视力表测量双眼的最佳视力。对一名53岁患类风湿关节炎的女性患者进行了眼前节裂隙灯检查、验光、散瞳眼底检查、荧光素血管造影和视网膜造影。她服用氯喹6年,前来就诊时已停药1年。她的最佳矫正视力分别为20/200和20/40。裂隙灯检查显示右眼有人工晶状体,另一眼有核性白内障(1+/4),且双眼视轴下方角膜上皮下混浊。眼底检查显示黄斑区视网膜色素上皮萎缩。荧光素血管造影显示靶心样黄斑病变。报告一例由氯喹引起的典型角膜病变和黄斑病变。

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