Koletzko B
Kinderklinik Heinrich-Heine-Universität, Düsseldorf, Germany.
Acta Paediatr. 1992 Apr;81(4):302-6. doi: 10.1111/j.1651-2227.1992.tb12230.x.
Human diet contains large amounts of trans fatty acids originating primarily from hydrogenated fats. Consumption of trans fatty acids is considered safe for man, but side effects, including impaired biosynthesis of long-chain polyunsaturated fatty acids with 20 and 22 carbon atoms and reduced growth have been observed in animals. We studied whether or not there are indications of untoward effects of trans fatty acids in 29 premature infants (birth weight 1700 +/- 127 g, gestational age 33.6 +/- 1.4 weeks, mean +/- SD). Plasma samples obtained on day 4 of life were analysed for fatty acid composition. Trans octadecenoic acid and total trans fatty acids in plasma lipid fractions (% wt/wt) were not related to the precursor essential fatty acids linoleic and alpha-linolenic acids but correlated inversely to n - 3 and n - 6 long-chain polyunsaturated fatty acids and to the product/substrate ratios of long-chain polyunsaturate biosynthesis. Trans fatty acids were also inversely correlated to birth weight but not to gestational age. These data indicate a potential impairment of essential fatty acid metabolism and early growth by trans isomers in man, and question the safety of high dietary trans isomer intakes during pregnancy and the perinatal period.
人类饮食中含有大量主要源自氢化脂肪的反式脂肪酸。反式脂肪酸的摄入被认为对人类是安全的，但在动物身上已观察到一些副作用，包括含20和22个碳原子的长链多不饱和脂肪酸生物合成受损以及生长减缓。我们研究了29名早产儿（出生体重1700±127克，胎龄33.6±1.4周，均值±标准差）是否有反式脂肪酸不良影响的迹象。分析了出生后第4天采集的血浆样本的脂肪酸组成。血浆脂质组分中的反式十八碳烯酸和总反式脂肪酸（%重量/重量）与前体必需脂肪酸亚油酸和α-亚麻酸无关，但与n-3和n-6长链多不饱和脂肪酸以及长链多不饱和物生物合成的产物/底物比率呈负相关。反式脂肪酸也与出生体重呈负相关，但与胎龄无关。这些数据表明反式异构体可能会损害人类必需脂肪酸代谢和早期生长，并对孕期和围产期高膳食反式异构体摄入量的安全性提出质疑。
