Murphy B F, McDonald I, Fairley K F, Kincaid-Smith P S
Department of Nephrology, St. Vincent's Hospital, Fitzroy, Victoria, Australia.
Clin Nephrol. 1992 May;37(5):229-34.
40 patients with idiopathic membranous glomerulonephritis were randomized to receive either no treatment or a regime of cyclophosphamide for 6 months, and warfarin and dipyridamole for two years. During the two years of the trial there was no significant deterioration in renal function in either group. A significantly greater improvement in urinary protein excretion was, however, observed at all time points in the treatment group. Plasma albumin was also significantly higher in the treatment group at 18 and 24 months. As progressive deterioration in renal function in membranous glomerulonephritis is associated with persistent heavy proteinuria these results suggest a beneficial effect of treatment.
40例特发性膜性肾小球肾炎患者被随机分为两组，一组不接受治疗，另一组接受为期6个月的环磷酰胺治疗，以及为期两年的华法林和双嘧达莫治疗。在试验的两年期间，两组患者的肾功能均未出现显著恶化。然而，在治疗组的所有时间点均观察到尿蛋白排泄有显著更大程度的改善。在18个月和24个月时，治疗组的血浆白蛋白也显著更高。由于膜性肾小球肾炎患者肾功能的进行性恶化与持续性大量蛋白尿有关，这些结果提示治疗具有有益作用。
