Jordan Jens F, Joergens Silke, Dinslage Sven, Dietlein Thomas S, Krieglstein Günter K
University Eye Hospital, University of Cologne, Joseph-Stelzmann-Str. 9, 50931, Cologne, Germany.
Graefes Arch Clin Exp Ophthalmol. 2006 Feb;244(2):177-82. doi: 10.1007/s00417-005-0053-0. Epub 2005 Aug 2.
The difference in central corneal thickness among subgroups of glaucoma patients, as well as its influence on Goldmann applanation tonometry, has been well documented in several clinical trials. In the present study, possible similarities and differences between central corneal thickness and corneal thickness of paracentral quadrants in patients with normal tension glaucoma (NTG) and ocular hypertension (OHT) were investigated.
Central and paracentral corneal thickness was measured by optical slit scan pachymetry (Orbscan II). Fourteen patients (28 eyes) with NTG and 11 patients (22 eyes) with OHT were included in this study. t-Test was performed for statistical analysis. To evaluate overall corneal topography, the mean and SD values of the differences between the central corneal thickness and each peripheral quadrant were analysed.
The following data was obtained (microm): (central, upper, temporal, nasal, inferior paracentral quadrant): OHT group 617-695-663-687-660. NTG group 568-629-593-612-616. Corneal thickness of all four paracentral quadrants differed significantly between the OHT and NTG groups. There was a more heterogeneous intraindividual pattern of overall corneal topography in the OHT group, and a more heterogeneous pattern of corneal topography among the individuals of the NTG group (interindividual heterogeneity).
A comparison of central corneal thickness and paracentral corneal thickness revealed clinically relevant differences between the OHT and NTG groups. The presented data underlines the importance of correlating the site of applanation with the corresponding corneal thickness, especially in OHT patients. It further substantiates the necessity to obtain individual pachymetric data for each NTG patient.
青光眼患者亚组之间中央角膜厚度的差异及其对Goldmann压平眼压计测量结果的影响，已在多项临床试验中得到充分记录。在本研究中，我们调查了正常眼压性青光眼（NTG）和高眼压症（OHT）患者中央角膜厚度与旁中央象限角膜厚度之间可能存在的异同。
采用光学裂隙扫描测厚法（Orbscan II）测量中央和旁中央角膜厚度。本研究纳入了14例（28只眼）NTG患者和11例（22只眼）OHT患者。采用t检验进行统计学分析。为评估整体角膜地形图，分析了中央角膜厚度与每个周边象限之间差异的均值和标准差。
获得以下数据（微米）：（中央、上方、颞侧、鼻侧、下方旁中央象限）：OHT组617 - 695 - 663 - 687 - 660。NTG组568 - 629 - 593 - 612 - 616。OHT组和NTG组所有四个旁中央象限的角膜厚度均存在显著差异。OHT组整体角膜地形图的个体内模式更为不均一，而NTG组个体间角膜地形图模式更为不均一（个体间不均一性）。
中央角膜厚度与旁中央角膜厚度的比较显示，OHT组和NTG组之间存在临床相关差异。所呈现的数据强调了将压平部位与相应角膜厚度相关联的重要性，尤其是在OHT患者中。这进一步证实了为每位NTG患者获取个体测厚数据的必要性。
